1132653-79-2

Basic information

• Product Name: Robotnikinin
• Synonyms: Robotnikinin;N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide;N-[(4-chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
• CAS NO: 1132653-79-2
• Molecular Formula: C₂₅H₂₇ClN₂O₄
• Molecular Weight: 454.946
• Mol File: 1132653-79-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Robotnikinin(CAS DataBase Reference)
• NIST Chemistry Reference: Robotnikinin(1132653-79-2)
• EPA Substance Registry System: Robotnikinin(1132653-79-2)

Safety Data

• Hazardous Substances Data: 1132653-79-2(Hazardous Substances Data)

Upstream product

• 851518-40-6 (S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoic acid 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 1132653-75-8 (S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-N-(4-chlorobenzyl)hex-5-enamide 
• 1132653-77-0 (S)-2-allyl-N₄-(4-chlorobenzyl)-N₁-((R)-2-hydroxy-2-phenylethyl)succinamide 
• 1132653-76-9 (S)-2-(2-(4-chlorobenzylamino)-2-oxoethyl)pent-4-enoic acid 
• 851518-35-9 (S)-tert-butyl 3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoate 
• 1192277-18-1 2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetic acid 
• 104-86-9 4-chlorobenzylamine 
• 1192277-12-5 (S)-tert-butyl 3-((R)-2-(pent-4-enoyloxy)-2-phenylethylcarbamoyl)hex-5-enoate 
• 1192277-10-3 (S)-tert-butyl 3-((R)-2-hydroxy-2-phenylethylcarbamoyl)hex-5-enoate 
• 1192277-14-7 tert-butyl 2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetate 
• 1132653-78-1 (R)-2-((S)-2-(2-(4-chlorobenzylamino)-2-oxoethyl)pent-4-enamido)-1-phenylethyl pent-4-enoate 

Downstream Products

• 1589555-12-3 N-(4-chlorobenzyl)-2-((2R,6S,8S,9S)-8,9-dihydroxy-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododecan-6-yl)acetamide 
• 1589554-39-1 N-(4-chlorobenzyl)-2-((3aS,8R,12S,13aS)-2,2-dimethyl-6,11-dioxo-8-phenyldecahydro-3aH-[1,3]dioxolo[4,5-h][1,4]oxaazacyclododecin-12-yl)acetamide 
• 1589555-11-2 N-(4-chlorobenzyl)-2-((1S,6R,10S,12S)-4,9-dioxo-6-phenyl-5,13-dioxa-8-azabicyclo[10.1.0]tridecan-10-yl)acetamide 

Relevant articles and documents

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We report the synthesis and biological activity of a library of aminoalcohol-derived macrocycles from which robotnikinin (17), a binder to and inhibitor of Sonic Hedgehog, was derived. Using an asymmetric alkylation to set a key stereocenter and an RCM re