1132653-79-2

Upstream product

• 851518-40-6 (S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoic acid 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 1132653-75-8 (S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)-N-(4-chlorobenzyl)hex-5-enamide 
• 1132653-77-0 (S)-2-allyl-N₄-(4-chlorobenzyl)-N₁-((R)-2-hydroxy-2-phenylethyl)succinamide 
• 1132653-76-9 (S)-2-(2-(4-chlorobenzylamino)-2-oxoethyl)pent-4-enoic acid 
• 851518-35-9 (S)-tert-butyl 3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoate 
• 1192277-18-1 2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetic acid 
• 104-86-9 4-chlorobenzylamine 
• 1192277-12-5 (S)-tert-butyl 3-((R)-2-(pent-4-enoyloxy)-2-phenylethylcarbamoyl)hex-5-enoate 
• 1192277-10-3 (S)-tert-butyl 3-((R)-2-hydroxy-2-phenylethylcarbamoyl)hex-5-enoate 
• 1192277-14-7 tert-butyl 2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetate 
• 1132653-78-1 (R)-2-((S)-2-(2-(4-chlorobenzylamino)-2-oxoethyl)pent-4-enamido)-1-phenylethyl pent-4-enoate 

Downstream Products

• 1589555-12-3 N-(4-chlorobenzyl)-2-((2R,6S,8S,9S)-8,9-dihydroxy-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododecan-6-yl)acetamide 
• 1589554-39-1 N-(4-chlorobenzyl)-2-((3aS,8R,12S,13aS)-2,2-dimethyl-6,11-dioxo-8-phenyldecahydro-3aH-[1,3]dioxolo[4,5-h][1,4]oxaazacyclododecin-12-yl)acetamide 
• 1589555-11-2 N-(4-chlorobenzyl)-2-((1S,6R,10S,12S)-4,9-dioxo-6-phenyl-5,13-dioxa-8-azabicyclo[10.1.0]tridecan-10-yl)acetamide 

Relevant academic research and scientific papers

SONIC HEDGEHOG MODULATORS

Sonic Hedgehog modulators and methods of use thereof are provided for.

SONIC HEDGEHOG MODULATORS

The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in t

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

We report the synthesis and biological activity of a library of aminoalcohol-derived macrocycles from which robotnikinin (17), a binder to and inhibitor of Sonic Hedgehog, was derived. Using an asymmetric alkylation to set a key stereocenter and an RCM re