1132667-46-9Relevant academic research and scientific papers
Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates
Zwick, Vincent,Nurisso, Alessandra,Sim?es-Pires, Claudia,Bouchet, Samuel,Martinet, Nadine,Lehotzky, Attila,Ovadi, Judit,Cuendet, Muriel,Blanquart, Christophe,Bertrand, Philippe
, p. 154 - 159 (2016)
Conditions for the metathesis of alkenes in the convergent synthesis of HDAC inhibitors have been improved by continuous catalyst flow injection in the reaction media. Intermediate and target compounds obtained were tested for their ability to induce HDAC
METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF
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Paragraph 00173, (2016/09/26)
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
