1132670-72-4Relevant academic research and scientific papers
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead
Williams, Richard,Niswender, Colleen M.,Luo, Qingwei,Le, Uyen,Conn, P. Jeffrey,Lindsley, Craig W.
, p. 962 - 966 (2009)
This Letter describes the synthesis and SAR of two mGluR4 positive allosteric modulator leads, 6 and 7. VU001171 (6) represents the most potent (EC50 = 650 nM), efficacious (141% Glu Max) and largest fold shift (36-fold) of any mGluR4 PAM repor
