1132709-93-3Relevant academic research and scientific papers
Aminophosphonic acids and aminobis(phosphonic acids) as potential inhibitors of penicillin-binding proteins
Beck, Josephine,Gharbi, Sonia,Herteg-Fernea, Adriana,Vercheval, Lionel,Bebrone, Carine,Lassaux, Patricia,Zervosen, Astrid,Marchand-Brynaert, Jacqueline
experimental part, p. 85 - 97 (2009/06/18)
Aminophosphonic acids and aminobis(phosphonic acids) have been prepared by the alkylation of Schiff bases with methyl bromoacetate or ethyl acrylate. Other pathways, like the modified Pudovik reaction and Kabachnik-Fields reaction, have been considered for the synthesis of the α-phosphonic bioisoster of aminocitrate. Partial or complete deprotection of the phosphonate ester have been realised by either acidic hydrolysis or by treatment with trimethylsilyl bromide. Evaluation against penicillin-binding proteins has shown that our compounds are modest inhibitors of class A β-lactamases, but have an interesting activity against R39 (D,D-peptidase/carboxypeptidase). Wiley-VCH Verlag GmbH & Co. KGaA, 2009.
