1132757-67-5

Basic information

• Product Name: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal
• Synonyms: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal
• CAS NO: 1132757-67-5
• Molecular Weight: 360.456
• Mol File: 1132757-67-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal(1132757-67-5)
• EPA Substance Registry System: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal(1132757-67-5)

Safety Data

• Hazardous Substances Data: 1132757-67-5(Hazardous Substances Data)

Upstream product

• 4185-69-7 1-(2,4-dinitrophenyl)-pyridinium chloride 
• 7390-67-2 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine 
• 40418-44-8 (2E,4E)-5-hydroxypenta-2,4-dienal potassium salt 

Relevant articles and documents

A sequential cycloaddition strategy for the synthesis of Alsmaphorazine B traces a path through a family of Alstonia alkaloids

Driven by a new biogenetic hypothesis, the first total synthesis of alsmaphorazine B and several related indole alkaloids has been achieved. Numerous early approaches proved unsuccessful owing to unproductive side reactivity; nevertheless, they provided important clues that guided the evolution of our strategy. Critical to our success was a major improvement in our Zincke aldehyde cycloaddition strategy, which permitted the efficient gram-scale synthesis of akuammicine. The sequential chemoselective oxidations of akuammicine leading up to the key oxidative rearrangement also yielded several biogenetically related indole alkaloids en route to alsmaphorazine B.