113276-96-3Relevant articles and documents
Synthesis of the β-lactone esterase inhibitor valilactone using πallyltricarbonyliron lactone complexes
Bates, Roderick W.,Fernandez-Moro, Rosalina,Ley, Steven V.
, p. 2651 - 2654 (1991)
Synthesis of the esterase inhibitor valilactone (1) is reported employing the oxidation of π-allyltricarbonyliron lactone complexes with ceric ammonium nitrate to afford the inherent β-lactone ring.
BETA-LACTONE COMPOUNDS
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Page/Page column 21; 42, (2009/05/28)
The present invention provides compounds having the general structure A, or a pharmaceutically acceptable derivatives thereof: wherein R is an alkyl group, and R1 comprises at least one moiety selected from a group consisting of an alkyl, an alkenyl, an aryl, a heterocycle, hydroxyl, ester, amido, aldehyde, and a halogen.
An expeditious enantioselective total synthesis of valilactone
Wu, Yikang,Sun, Ya-Ping
, p. 5748 - 5751 (2007/10/03)
The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic centers and a hydroxyl group activation (HGA) protocol to construct the anti α,β-disubstituted β-lactone from the corresponding syn aldol.
