1132814-55-1

Basic information

• Product Name: ethyl 3-{[1-(2-hydroxyethyl)cyclopentyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate
• Synonyms: ethyl 3-{[1-(2-hydroxyethyl)cyclopentyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate
• CAS NO: 1132814-55-1
• Molecular Weight: 403.374
• Mol File: 1132814-55-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-{[1-(2-hydroxyethyl)cyclopentyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-{[1-(2-hydroxyethyl)cyclopentyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate(1132814-55-1)
• EPA Substance Registry System: ethyl 3-{[1-(2-hydroxyethyl)cyclopentyl]amino}-2-(2,3,4,5-tetrafluorobenzoyl)acrylate(1132814-55-1)

Safety Data

• Hazardous Substances Data: 1132814-55-1(Hazardous Substances Data)

Upstream product

• 120-92-3 cyclopentanone 
• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 3197-76-0 ethyl 2-(1-hydroxycyclopentyl)acetate 
• 896734-87-5 1-amino-1-(2-hydroxyethyl)cyclopentane 
• 94714-58-6 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 79660-46-1 ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Relevant articles and documents

Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics

The design, synthesis, and evaluation of 6-6-7 tricyclic quinolones containing the strained spirocycle moiety aiming at the GSK-3β inhibitor were described. Among the synthesized compounds, 44, having a cyclobutane ring on a spirocycle, showed excellent GSK-3β inhibitory activity in both cell-free and cell-based assays (IC50 = 36 nM, EC50 = 3.2 μM, respectively). Additionally, 44 decreased the plasma glucose concentration dose-dependently after an oral glucose tolerance test in mice.