113282-74-9

Usage

Uses

Used in Pharmaceutical Research:
(2Z)-2-HYDROXY-4-(4-METHYLPHENYL)-4-OXOBUT-2-ENOIC ACID is used as a research compound for its potential pharmacological and therapeutic properties. Its antioxidant and anti-inflammatory effects make it a promising candidate for the development of new medications.
Used in Organic Synthesis:
(2Z)-2-HYDROXY-4-(4-METHYLPHENYL)-4-OXOBUT-2-ENOIC ACID is used as a key intermediate in organic synthesis, allowing for the creation of various chemical compounds and pharmaceuticals.
Used in Antioxidant and Anti-Inflammatory Applications:
(2Z)-2-HYDROXY-4-(4-METHYLPHENYL)-4-OXOBUT-2-ENOIC ACID is used as an antioxidant and anti-inflammatory agent, potentially beneficial in the treatment of various conditions and diseases.
Further research is necessary to fully understand the biological and pharmacological properties of (2Z)-2-HYDROXY-4-(4-METHYLPHENYL)-4-OXOBUT-2-ENOIC ACID and to explore its potential applications in various industries.

Upstream product

• 122-00-9 para-methylacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 113416-42-5 5-methoxycarbonyl-3,5-dihydroxy-4-p-toluoyl-1-phenyl-2,5-dihydro-2-pyrrolone 
• 113416-20-9 (Z)-4-Oxo-2-phenylamino-4-p-tolyl-but-2-enoic acid methyl ester 
• 113416-52-7 4-Hydroxy-2-methoxy-3-(4-methyl-benzoyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 
• 113416-31-2 3-(4-Methyl-benzoyl)-4,5-dioxo-1-phenyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 1196034-07-7 4-(4-methylphenyl)-4-oxo-2-[N-(4-ethoxycarbonylphenyl)]aminobut-2-enoic acid 
• 1196034-04-4 2-(2-methyl-5-nitrophenylamino)-4-(4-methylphenyl)-4-oxobut-2-enoic acid 
• 1283714-67-9 2-{2-[(4-methoxyphenyl)(phenyl)methylidene]hydrazino}-4-(4-methylphenyl)-4-oxobut-2-enoic acid 
• 1283714-66-8 (2Z)-2-{(E)-2-[(4-methoxyphenyl)(phenyl)methylidene]hydrazino}-4-(4-methylphenyl)-4-oxobut-2-enoic acid 
• 1283714-81-7 (2Z)-2-[2-(9H-fluoren-9-ylidene)hydrazino]-4-(4-methylphenyl)-4-oxobut-2-enoic acid 
• 1283714-82-8 2-[2-(9H-fluoren-9-ylidene)hydrazino]-4-(4-methylphenyl)-4-oxobut-2-enoic acid 

Relevant academic research and scientific papers

Redox properties of alkyl-substituted 4-aryl-2,4-dioxobutanoic acids

Redox properties of a set of aryldiketo acids (ADKs), small organic molecules that comprise 2,4-dioxobutanoic acid moiety, were studied. Along with well-known HIV-1 integrase (IN) inhibition, ADKs exert widespread biological activities. The aim of this work was to evaluate the effects of aryl substitutions on the properties of the dioxobutanoic moiety that is involved in key interactions with metal ions within the active sites of target enzymes. The effect of pH on the electronic properties of nine congeners was examined using cyclic voltammetry and differential pulse polarography. The compounds were chosen as a simple set of congeners bearing Me-groups on the phenyl ring, which should not be involved in electrochemical reactions, leaving the diketo moiety as the sole electrophore. The substitution pattern was systematically varied, yielding a set having different torsion between the phenyl ring and the aryl keto group (Ar-C(O)). The protonation state of the ADKs at different pH values was determined from the experimentally obtained pKa values. The results showed that an equal number of protons and electrons were involved in the oxidation and reduction reactions at the surface of the electrode. Quantitative linear correlations were found between the reduction potentials and the energies of the frontier orbitals, calculated for neutral, mono-anionic and the corresponding radical anionic species, and the steric parameter as two independent variables.

FIVE-MEMBERED 2,3-DIOXOHETEROCYCLES. V. SYNTHESIS OF 1-ARYL-4-AROYL-5-METHOXYCARBONYL-2,3-DIHYDRO-2,3-PYRROLEDIONES AND THEIR REACTIONS WITH WATER AND ALCOHOLS

1-Aryl-4-aroyl-5-methoxycarbonyl-2,3-dihydro-2,3-pyrrolediones were obtained from oxalyl chloride and methyl 4-aryl-2-arylamino-4-oxo-2-butenoates.They add water and alcohols reversibly with the formation of substituted 3,5-dihydroxy- and 5-alkoxy-3-hydro