113296-80-3

Basic information

• Product Name: 2,5-Piperazinedione, 3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,4,5-trimethoxy-3-meth ylphenyl)methylene]-, (Z)-
• CAS NO: 113296-80-3
• Molecular Formula: C26H32N2O8
• Molecular Weight: 500.549
• Mol File: 113296-80-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-Piperazinedione, 3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,4,5-trimethoxy-3-meth ylphenyl)methylene]-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione, 3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,4,5-trimethoxy-3-meth ylphenyl)methylene]-, (Z)-(113296-80-3)
• EPA Substance Registry System: 2,5-Piperazinedione, 3-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-6-[(2,4,5-trimethoxy-3-meth ylphenyl)methylene]-, (Z)-(113296-80-3)

Safety Data

• Hazardous Substances Data: 113296-80-3(Hazardous Substances Data)

Upstream product

• 137043-30-2 (3Z,6Z)-3,6-Bis-<(2,4,5-trimethoxy-3-methylphenyl)methylene>piperazinedione 
• 106-51-4 p-benzoquinone 
• 113296-73-4 1,4-diacetyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione 
• 113296-72-3 1-acetyl-3-(2,4,5-trimethoxy-3-methylphenyl)methyl-2,5-piperazinedione 
• 113296-74-5 (Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione 
• 60059-09-8 2,4,5-trimethoxy-3-methylbenzaldehyde 
• 113296-75-6 (Z)-1-acetyl-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione 

Downstream Products

• 113321-20-3 2,5-Bis-benzyloxy-3,6-bis-(2,4,5-trimethoxy-3-methyl-benzyl)-pyrazine 
• 113296-85-8 (Z)-1,4-dibenzyl-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione 
• 113296-89-2 (Z)-1-acetyl-5-benzyloxy-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-1,2,3,6-tetrahydropyrazin-2-one 
• 113296-90-5 2-benzyloxy-3,6-bis(2,4,5-trimethoxy-3-methylphenylmethyl)-5-hydroxypyrazine 
• 113461-79-3 (Z)-1-acetyl-4-benzyl-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione 
• 113461-80-6 (Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione 
• 113296-87-0 (Z)-5-benzyloxy-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-1,2,3,6-tetrahydropyrazin-2-one 
• 113296-75-6 (Z)-1-acetyl-6-(2,4,5-trimethoxy-3-methylphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione 

Relevant articles and documents

One-pot α-amidosulfone-mediated variation of the pictet-Spengler tetrahydroisoquinoline synthesis, suitable for amide-type substrates

The development of Pictet-Spengler reactions from amide substrates is a challenging problem. We report here that the reaction between amide-type compounds (including carbamates, amides, ureas and diketopiperazines), aldehydes and p-toluenesulfinic acid constitutes an efficient method for the preparation of tetrahydroisoquinolines or pyrazino-[2,1-b]isoquinolines. Unlike previously known methods, this one-pot Pictet-Spengler protocol avoids the need for strong Lewis or Br?nsted acid catalysts.

Preparations and reactions of (Z)-3-arylidene-6-arylmethyl-2,5-piperazinediones having highly oxygenated benzene rings

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