113301-07-8Relevant academic research and scientific papers
The synthesis of some 11-substituted tetrahydrocannabinol metabolites
ApSimon, John W.,Collier, T. Lee,Guiver, Michael D.
, p. 2804 - 2809 (2007/10/02)
9-Bromo-11-oxo-hexahydrocannabinol (5) was prepared from the ketocannabinoid 3b via the epoxysulfone 4.The dehydrobromination of the bromoaldehyde 5 could be controlled to give either the thermodinamically more stable Δ8-aldehyde 2c, or the Δ9-aldehyde 1c by an intramolecularly assisted elimination.Reduction of the unsaturated aldehydes gave the allylic alcohol metabolites 2a and 1a, respectively.
