113306-10-8

Upstream product

• 31523-22-5 3-hydrazino-5H-[1,2,4]triazino[5,6-b]indole 
• 100-52-7 benzaldehyde 
• 28668-95-3 2,5-dihydro-3H-1,2,4-triazino[5,6-b]indole-3-thione 

Downstream Products

• 113306-13-1 3-Phenyl-10H-1,2,4-triazolo<4',3':2,3><1,2,4>triazino<5,6-b>indole 
• 116505-49-8 1-phenyl-10H-[1,2,4]triazolo[3',4':3,4][1,2,4]triazino[5,6-b]indole 
• 140230-19-9 1-(3-Phenyl-1,2,3a,4,9,10-hexaaza-cyclopenta[b]fluoren-9-yl)-ethanone 
• 148066-05-1 (3-Phenyl-1,2,4-triazolo<4',3':2,3><1,2,4>triazino<5,6-b>indol-10-yl)(2-thiol-1,3,4-oxadiazol-5-yl)methane 
• 148065-95-6 10-Carbethoxymethyl-10H-3-phenyl-1,2,4-triazolo<4',3':2,3><1,2,4>triazino<5,6-b>indole 
• 148065-96-7 (3-Phenyl-1,2,4-triazolo<4',3':2,3><1,2,4>triazino<5,6-b>indol-10-yl)acetylhydrazine 

Relevant academic research and scientific papers

Syntheses and in vitro biological screening of 1-aryl-10H-[1,2,4] triazolo[3′,4′:3,4][1,2,4]triazino[5,6-b]indoles

Structurally diverse 1-aryl-10H-[1,2,4]triazolo[3′,4′:3,4][1,2, 4]triazino[5,6-b]indoles 4a-v were synthesized by regiospecific heterocyclizations. The designed molecular diversity was evaluated in vitro in parallel cell-based assays for cytotoxicity of viruses multiplication supporting cell lines and antiviral activity against viruses representative of two of three genera of the Flaviviridae family. The compound library was also tested against Retrovirus (HIV-1), two Picornaviruses (CVB-2 and Sb-1), and Paramyxoviridae (VSV) representative. Among double-stranded RNA (dsRNA) viruses, Reoviridae representative (Reo-1) was tested. Two representatives of DNA virus families were also included - HSV-1 (Herpesviridae) and VV (Poxviridae). The compounds 4m and 4o were found cytotoxic, having CC50 values ranging from 4 to 30 μM. Moreover, compound 4v has exhibited significant activity (EC50 = 3 μM) against BVDV.

New 5H-1,2,4-triazino[5,6-b]indole and aminoindole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation, anti-hypertensive agents and thromboxane synthetase inhibitors

This paper reports the synthesis of a series of 5H-1,2,4-triazino[5,6-b]indole 3 and 4, and aminoindole 12-23, derivatives, obtained from isatin 1 and from oxoindole 5, respectively. All the new compounds were studied as antihypertensive agents in spontaneously hypertensive rats (SHR), and as inhibitors of platelet aggregation in guinea pig whole blood, induced by arachidonic acid (AA), adenosin-5'-diphosphate (ADP) or collagen. The most active antiaggregating compounds were also studied as thromboxane A2 synthetase inhibitors.

Cyclization Reactions of 3-Hydrazinotriazinoindole

The reaction of 3-hydrazinotriazinoindole I with nitrous acid affords the azide III which could be cyclized with acetic anhydride to 10-acetyl-10H-tetrazolotriazinoindole IIb.Cyclization reactions of I with acetic an