1133062-79-9Relevant academic research and scientific papers
Catalytic Lewis acid phosphorylation with pyrophosphates
Fenton, Owen S.,Allen, Emily E.,Pedretty, Kyle P.,Till, Sean D.,Todaro, Joseph E.,Sculimbrene, Bianca R.
, p. 9023 - 9028 (2012/11/06)
We report a method for the Lewis acid catalyzed phosphorylation of alcohols with pyrophosphates. Ti(OtBu)4 was found to be the most effective catalyst in the phosphorylation of both primary and secondary alcohols with tetrabenzylpyrophosphate, providing conversions between 54% and >98% and isolated yields between 50% and 97%. Other pyrophosphates with orthogonal protecting groups were synthesized and screened to validate the generality of the approach. This study will describe how benzyl, methyl, ethyl, allyl, and o-nitrobenzyl pyrophosphates are all effective phosphorylating agents under Lewis acid catalysis.
Efficient catalyst turnover in the phosphitylation of alcohols with phosphoramidites
Brady, Patrick B.,Morris, Elizabeth M.,Fenton, Owen S.,Sculimbrene, Bianca R.
supporting information; experimental part, p. 975 - 978 (2009/05/27)
We report a method for catalytic phosphitylation utilizing phosphoramidites. Traditionally, this reaction is inefficient unless an excess of catalyst is present due to catalyst deactivation by an amine by-product. Isocyanate additives have been evaluated
