187600-98-2

Upstream product

• 612-25-9 2-Nitrobenzyl alcohol 
• 187601-04-3 C₁₉H₃₄N₃O₃P 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 552-89-6 2-nitro-benzaldehyde 
• 108-18-9 diisopropylamine 
• 187601-03-2 C₇H₆Cl₂NO₃P 

Downstream Products

• 197902-46-8 tris(2-nitrobenzyl)phosphite 
• 1404341-55-4 6-O-bis-(2-nitrobenzyloxyphosphoryl)-D-trehalose 
• 1133062-79-9 2-dodecyl di-o-nitrobenzyl phosphate 
• 197902-51-5 3-{4-[Bis-(2-nitro-benzyloxy)-phosphorylmethyl]-phenyl}-2-(3,4-dimethoxy-2-nitro-benzyloxycarbonylamino)-propionic acid cyanomethyl ester 
• 197902-49-1 3-{4-[Bis-(2-nitro-benzyloxy)-phosphorylmethyl]-phenyl}-2-(3,4-dimethoxy-2-nitro-benzyloxycarbonylamino)-propionic acid ethyl ester 
• 197902-50-4 3-{4-[Bis-(2-nitro-benzyloxy)-phosphorylmethyl]-phenyl}-2-(3,4-dimethoxy-2-nitro-benzyloxycarbonylamino)-propionic acid 
• 197902-48-0 2-(Benzhydrylidene-amino)-3-{4-[bis-(2-nitro-benzyloxy)-phosphorylmethyl]-phenyl}-propionic acid ethyl ester 
• 197902-47-9 (4-Bromomethyl-benzyl)-phosphonic acid bis-(2-nitro-benzyl) ester 
• 197902-45-7 (S)-3-{4-[Bis-(2-nitro-benzyloxy)-phosphoryloxy]-phenyl}-2-(3,4-dimethoxy-2-nitro-benzyloxycarbonylamino)-propionic acid cyanomethyl ester 

Relevant academic research and scientific papers

Photocaged and Mixed Photocaged Bioreversible-Protected ATP Derivatives as Tools for the Controlled Release of ATP

Adenosine triphosphate (ATP) is known as the universal energy source for cellular processes, in addition, ATP also plays an important role in inflammation and cell signaling. Extracellular ATP binds to purinergic receptors and initiates further immune responses. To investigate these processes in-depth and to understand the complex mechanism of purinergic signaling, chemical tools are necessary. Here we present the synthesis of different photocaged ATP derivatives and the investigation of the light-induced release of ATP depending on the different synthesized photocleavable protecting groups based on the 2-nitrobenzyl moiety. Furthermore, we also present the synthesis of a mixed protected ATP-derivative as an example for a novel class of lipophilically caged nucleoside triphosphates. This new type of compounds is protected with a highly lipophilic non-toxic bio-removable acyloxybenzyl group and a photocleavable group. This combination may allow both passive cell uptake and controlled release of ATP by irradiation with non-harmful UV light.

INDUCTION OF FLORAL DEVELOPMENT IN PLANTS

The present invention relates to methods and uses of photo-labile compounds which are trehalose-6-phosphate or trehalose-6-phosphonate or agriculturally acceptable salts thereof in the induction of floral development in plants. The invention also concerns

TREATING WATER STRESS IN PLANTS

The present invention relates to methods and uses of photo-labile compounds which are trehalose-6-phosphate or trehalose-6-phosphonate or agriculturally acceptable salts thereof in the treatment of water stress in plants. The invention also concerns methods and the use of the compounds for resurrection of water stressed plants, and for improvement of yield of crop plants under water stressed conditions compared with untreated plants.

Chemical intervention in plant sugar signalling increases yield and resilience

The pressing global issue of food insecurity due to population growth, diminishing land and variable climate can only be addressed in agriculture by improving both maximum crop yield potential and resilience. Genetic modification is one potential solution, but has yet to achieve worldwide acceptance, particularly for crops such as wheat. Trehalose-6-phosphate (T6P), a central sugar signal in plants, regulates sucrose use and allocation, underpinning crop growth and development. Here we show that application of a chemical intervention strategy directly modulates T6P levels in planta. Plant-permeable analogues of T6P were designed and constructed based on a 'signalling-precursor' concept for permeability, ready uptake and sunlight-triggered release of T6P in planta. We show that chemical intervention in a potent sugar signal increases grain yield, whereas application to vegetative tissue improves recovery and resurrection from drought. This technology offers a means to combine increases in yield with crop stress resilience. Given the generality of the T6P pathway in plants and other small-molecule signals in biology, these studies suggest that suitable synthetic exogenous small-molecule signal precursors can be used to directly enhance plant performance and perhaps other organism function.

MODIFICATION OF TREHALOSE-6-PHOSPHATE LEVELS IN PLANTS

Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants.

Structurally modified firefly luciferase. Effects of amino acid substitution at position 286

Ser was replaced at position 286 of firefly luciferase (Luciola mingrelica) by a series of naturally occurring and unnatural amino acids. The effect of these substitutions on the properties of luciferase, such as thermostability, pH dependence, and color

Regioselective synthesis of photolabile P(1,2)- and P(4,5)-(o-nitrobenzyl) esters of myo-inositol 1,2,3,4,5,6-hexakisphosphate

The regioselective synthesis of four caged InsP6 derivatives is described. The synthesis employed allyl ester protecting groups, and Rh(I) could selectively deprotect all allyl phosphates in a single step without affecting the photolabile moieties.