113310-52-4

Basic information

• Product Name: 4-(4-AMINOPHENYL)-PIPERIDINE
• Synonyms: 4-(Piperidin-4-yl)benzenamine;4-(4-Aminophenyl)-piperidine HCl
• CAS NO: 113310-52-4
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.26
• Mol File: 113310-52-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 328.329 °C at 760 mmHg
• Flash Point: 178.397 °C
• Appearance: /
• Density: 1.043 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.34±0.10(Predicted)
• CAS DataBase Reference: 4-(4-AMINOPHENYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-AMINOPHENYL)-PIPERIDINE(113310-52-4)
• EPA Substance Registry System: 4-(4-AMINOPHENYL)-PIPERIDINE(113310-52-4)

Safety Data

• Hazardous Substances Data: 113310-52-4(Hazardous Substances Data)

Usage

General Description

4-(4-aminophenyl)piperidine is a chemical compound with the molecular formula C11H16N2. It is a member of the piperidine class of chemicals, which are commonly used in pharmaceutical and industrial applications. The compound consists of a piperidine ring with a 4-aminophenyl group attached to one of the carbon atoms. This chemical is known to have potential applications in medicinal chemistry, particularly in the development of new drugs and pharmaceuticals. It may also be used as a building block in organic synthesis for the production of various other chemical compounds. Additionally, research suggests that 4-(4-aminophenyl)piperidine may have potential biological activities and therapeutic effects, making it a compound of interest in the field of drug discovery and development.

InChI:InChI=1/C11H16N2/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-4,10,13H,5-8,12H2

Upstream product

• 26905-03-3 4-(4-Nitrophenyl)piperidine 
• 771-99-3 4-phenylpiperidine 

Downstream Products

• 1023277-57-7 4-(1-propyl-4-piperidyl)aniline 
• 1369588-94-2 4-[4-(1-propyl-4-piperidyl)phenyl]morpholine 
• 1217709-64-2 C₂₀H₁₉N₃O 
• 1166817-01-1 C₁₇H₁₇F₃N₆ 

Relevant articles and documents

Development of novel ACK1/TNK2 inhibitors using a fragment-based approach

The tyrosine kinase ACK1, a critical signal transducer regulating survival of hormone-refractory cancers, is an important therapeutic target, for which there are no selective inhibitors in clinical trials to date. This work reports the discovery of novel and potent inhibitors for ACK1 tyrosine kinase (also known as TNK2) using an innovative fragment-based approach. Focused libraries were designed and synthesized by selecting fragments from reported ACK inhibitors to create hybrid structures in a mix and match process. The hybrid library was screened by enzyme-linked immunosorbent assay-based kinase inhibition and 33P HotSpot assays. Systematic structure-activity relationship studies led to the identification of compound (R)-9b, which shows potent in vitro (IC50 = 56 nM, n = 3, 33P HotSpot assay) and in vivo (IC50 1/2 > 6 h).

INHIBITORS OF ACK1/TNK2 TYROSINE KINASE

Described are cancer therapies and anti-cancer compounds. In particular, disclosed are ihibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specifc example, compound having Formula I through IV are disclosed.