113331-50-3

Upstream product

• 113331-49-0 2(S)-(1'(S)-hydroxy-2'-phenoxy)-3(S)-(trimethylsilyl)oxirane 
• 1071041-37-6 4-Nitro-benzoic acid (S)-2-phenoxy-1-(3-trimethylsilanyl-oxiranyl)-ethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 113331-49-0 (S)-2-Phenoxy-1-(3-trimethylsilanyl-oxiranyl)-ethanol 
• 113331-49-0 (R)-2-Phenoxy-1-(3-trimethylsilanyl-oxiranyl)-ethanol 
• 113428-13-0 1-phenoxy-4-(trimethylsilyl)-3(E)-buten-2(S)-ol 
• 113331-48-9 1-phenoxy-4-(trimethylsilyl)-2(E)-buten-2-ol 

Downstream Products

• 433213-41-3 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether) 
• 433213-42-4 3,7-dithia-16-phenoxy-ω-tetranorprostaglandin E₁ methyl ester 

Relevant academic research and scientific papers

A HIGHLY EFFICIENT SYNTHESIS OF γ-HALO ALLYLIC ALCOHOLS AND PROPARGYLIC ALCOHOLS WITH OPTICAL PURITY. PRACTICAL METHOD FOR SYNTHESIS OF THE PROSTAGLANDIN ω-CHAIN.

Kinetic resolution of γ-trimethylsilyl allylic alcohols 5 by the Sharpless process combined with the reactivity of epoxysilyl or vinylsilyl compounds affords a highly efficient method for preparation of optically pure γ-halo secondary allylic alcohols of type 1-4 and propargylic alcohols 14, thus providing a practical route to the prostaglandin ω-chain.