433213-41-3

Basic information

• Product Name: 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether)
• Synonyms: 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether)
• CAS NO: 433213-41-3
• Molecular Weight: 669.107
• Mol File: 433213-41-3.mol

Chemical Properties

• CAS DataBase Reference: 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether)(433213-41-3)
• EPA Substance Registry System: 3,7-dithia-16-phenoxy-ω-tetranorPGE₁ methyl ester 11,15-bis(tert-butyldimethylsilyl ether)(433213-41-3)

Safety Data

• Hazardous Substances Data: 433213-41-3(Hazardous Substances Data)

Upstream product

• 164214-15-7 6-mercapto-3-thiahexanoic acid methyl ester 
• 113331-50-3 tert-Butyl-((E)-(R)-3-iodo-1-phenoxymethyl-allyloxy)-dimethyl-silane 
• 210819-03-7 2-(6-carbomethoxy-1,5-dithiahexyl)-4-(R)-tert-butyldimethylsilyloxy-2-cyclopentenone 

Downstream Products

• 433213-42-4 3,7-dithia-16-phenoxy-ω-tetranorprostaglandin E₁ methyl ester 

Relevant articles and documents

Design and synthesis of a selective EP4-receptor agonist. Part 1: Discovery of 3,7-dithiaPGE1 derivatives and identification of their ω chains

Improvement of EP4-receptor selectivity and the agonist activity by introduction of heteroatoms into the α chain of PGE1 was investigated. Among the compounds tested, 3,7-dithiaPGE1 4a exhibited good EP4-receptor selectivity and agonist activity. Further modification of the ω chain of 3,7-dithiaPGE1 was performed to improve EP4-receptor selectivity and agonist activity. Of the compounds produced, 16-phenyl-ω-tetranor-3,7-dithiaPGE1 4p possessing moderate EP4-receptor selectivity and agonist activity, was identified as a new chemical lead for further optimization by modification of the aromatic moiety. Copyright