113352-66-2

Basic information

• Product Name: 1-(4-Methoxy-2-nitrophenyl)propan-2-one
• Synonyms: 1-(4-Methoxy-2-nitrophenyl)propan-2-one
• CAS NO: 113352-66-2
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• Mol File: 113352-66-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-Methoxy-2-nitrophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxy-2-nitrophenyl)propan-2-one(113352-66-2)
• EPA Substance Registry System: 1-(4-Methoxy-2-nitrophenyl)propan-2-one(113352-66-2)

Safety Data

• Hazardous Substances Data: 113352-66-2(Hazardous Substances Data)

Usage

Description

1-(4-Methoxy-2-nitrophenyl)propan-2-one is a nitroaromatic chemical compound characterized by the molecular formula C10H11NO4. It is a yellow solid with a molecular weight of 221.199 g/mol, known for its aromatic and aliphatic properties. 1-(4-Methoxy-2-nitrophenyl)propan-2-one is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds, and is also utilized in the production of dyes, pigments, and other industrial applications due to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
1-(4-Methoxy-2-nitrophenyl)propan-2-one is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Organic Chemistry:
1-(4-Methoxy-2-nitrophenyl)propan-2-one is used as a reactant in various organic chemistry reactions, facilitating the formation of different organic compounds and aiding in the advancement of chemical research.
Used in Dye and Pigment Production:
1-(4-Methoxy-2-nitrophenyl)propan-2-one is used in the production of dyes and pigments, providing unique color properties and enhancing the quality of these products for various applications.
Used in Other Industrial Applications:
Due to its reactivity and chemical properties, 1-(4-Methoxy-2-nitrophenyl)propan-2-one is also utilized in other industrial applications, contributing to the development and improvement of various products and processes.

Upstream product

• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 5344-78-5 4-bromo-3-nitroanizole 
• 123-92-2 3-methyl-1-butyl acetate 
• 67-64-1 acetone 
• 108-22-5 Isopropenyl acetate 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 113352-70-8 C₃₁H₃₂N₂O₅S 
• 113352-69-5 C₃₁H₃₂N₂O₄S 
• 113352-71-9 C₃₁H₃₀N₂O₄S 
• 113689-23-9 C₃₁H₃₀N₂O₄S 
• 113774-79-1 (3aR,10bS,11S,12bS)-8-Methoxy-1-oxo-11-phenylsulfanyl-3a,11,12,12b-tetrahydro-1H,4H-6,12a-diaza-indeno[7,1-cd]fluorene-6-carboxylic acid methyl ester 
• 113352-98-0 C₃₃H₃₆N₂O₅S 
• 113352-98-0 C₃₃H₃₆N₂O₅S 
• 113352-99-1 C₃₃H₃₄N₂O₄S 
• 113352-99-1 C₃₃H₃₄N₂O₄S 
• 113352-99-1 C₃₃H₃₄N₂O₄S 
• 113352-91-3 C₃₃H₃₆N₂O₄S 
• 113352-91-3 C₃₃H₃₆N₂O₄S 
• 113352-76-4 (3aR,10bS,11R,12bS)-3a-Ethyl-8-methoxy-1-oxo-11-phenylsulfanyl-3a,11,12,12b-tetrahydro-1H,4H-6,12a-diaza-indeno[7,1-cd]fluorene-6-carboxylic acid methyl ester 
• 113378-64-6 2,3,6,7-tetradehydro-1-carbomethoxy-11β-(phenylthio)-16-methoxyaspidospermidin-8-one 

Relevant articles and documents

A practical synthesis of α-aryl methyl ketones via a transition-metal-free Meerwein arylation

We report herein a simple, scalable, transition-metal-free approach to the synthesis of α-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one.

C-C Activation by Retro-Aldol Reaction of Two β-Hydroxy Carbonyl Compounds: Synergy with Pd-Catalyzed Cross-Coupling to Access Mono-α-arylated Ketones and Esters

A retro-aldol reaction of two β-hydroxy compounds in synergy with Pd-catalyzed cross-coupling of aryl halides is reported herein, which produces selectively mono-α-arylated ketones and esters in good yields. This reaction is compatible with a broad range of aryl iodides, bromides, chlorides, and triflates and can tolerate an array of functional groups on the aromatic ring. Ready scale-up of this reaction to gram level is applicable without an appreciable decrease in the reaction yield. Furthermore, concise syntheses of biologically active isocoumarin and indole derivatives have been achieved to greatly demonstrate the synthetic value of this retro-aldol reaction. Finally, the reaction mechanism has been discussed on the basis of experimental observations and DFT computational results. A regulated six-membered-ring transition structure has been located for the key retro-aldol C-C cleavage, which constitutes the rate-determining step of a full catalytic cycle. The concept of C-C activation by retro-aldol reaction may also find applications in other fundamental reactions.

OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use