113368-98-2Relevant academic research and scientific papers
Column chromatography-free solution-phase synthesis of a natural piper-amide-like compound library
Kiim, Sumin,Lim, Chaemin,Lee, Sukjin,Lee, Seokwoo,Cho, Hyunkyung,Lee, Joo-Youn,Shim, Dong Sup,Park, Hee Dong,Kim, Sanghee
supporting information, p. 208 - 215 (2013/05/22)
We have achieved an efficient solution-phase parallel synthesis of a library of natural piper-amide-like compounds from the bifunctional β-phosphono-N-hydroxy-succinimidyl ester intermediate. The primary important feature in our study is the construction of natural-product-like molecules through the adaptation of sophisticated organic reactions that create water-soluble byproducts for a chromatography-free purification. This simple and efficient method rapidly provides a combinatorial library of high yield and purity. The library was evaluated against GPCR targets to demonstrate its potential use as a tool for drug discovery and in chemical biology.
EFFICIENT ESTER EXCHANGE REACTION OF PHOSPHONOACETATES
Hatakeyama, Susumi,Satoh, Kumiko,Sakurai, Kuniya,Takano, Seiichi
, p. 2713 - 2716 (2007/10/02)
A novel method for the preparation of differentially substituted phosphonoacetates and phosphonoacetamides using 4-DMAP catalyzed ester exchange reaction has been developed.
