1133769-93-3

Upstream product

• 1133770-45-2 (1S,4R)(2Z)-1-[(4-methoxyphenyl)methoxy]-2-methyl-1-prop-2-enyl-4-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]hex-2-ene 
• 1250395-63-1 2-propenyl (2Z,5S,8R,6Z)-3-amino-8-[(tert-butyldimethylsilyloxy)methyl]-5-(4-methoxyphenylmethoxy)-6-methyl-2,6-decadienoate 
• 1250395-70-0 C₁₉H₂₈O₄ 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1250395-71-1 methyl (2S,3R,5S,7R,8R,9S,11S,15S,16Z,18R)-8-(tert-butyldimethylsilyloxy)-18-[(tertbutyldimethylsilyloxy)methyl]-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-3,7-dimethoxy-9,15-bis(4-methoxyphenylmethoxy)-2-(methoxymethoxy)-10,10,16-trimethyl-13-oxo-16-icosenoate 

Relevant academic research and scientific papers

Total synthesis of peloruside a through kinetic lactonization and relay ring-closing metathesis cyclization reactions

The other side: A convergent total synthesis of peloruside A (1) is described. The key strategic features are a diastereoselective lactonization to generate a C5-C9 valerolactone from the C2-symmetric ketone 3, and a relay ring-closing metathesis reaction to produce a dehydrovalerolactone 2. A new isomer of 1, the valerolactone isopeloruside A (iso-1), was identified. MOM=methoxymethyl.