1133853-52-7

Basic information

• Product Name: 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine
• Synonyms: 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine
• CAS NO: 1133853-52-7
• Molecular Weight: 278.277
• Mol File: 1133853-52-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(1133853-52-7)
• EPA Substance Registry System: 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(1133853-52-7)

Safety Data

• Hazardous Substances Data: 1133853-52-7(Hazardous Substances Data)

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 253-72-5 1,6-naphthyridine 
• 1133853-45-8 ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate 
• 1133853-49-2 ethyl 5-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 

Downstream Products

• 1133853-51-6 N-(4-fluorophenyl)-5-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide 
• 1133853-53-8 (R)-N-(4-fluorophenyl)-5-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide 

Relevant articles and documents

Synthesis of Tetrahydronaphthyridines from Aldehydes and HARP Reagents via Radical Pictet-Spengler Reactions

The combination of aldehydes with newly designed HARP (halogen amine radical protocol) reagents gives access to α-substituted tetrahydronaphthyridines. By using different HARP reagents, various regioisomeric structures can be prepared in a single operation. These products, which are of high value in medicinal chemistry, are formed in a predictable manner via a formal Pictet-Spengler reaction of electron-poor pyridines that would not participate in the corresponding polar reactions.

Vanilloid receptor ligands and their use in treatments

Bicyclic 3,4-fused piperidine compounds, and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.