253-72-5

Basic information

• Product Name: 1,6-NAPHTHYRIDINE
• Synonyms: 1,6-DIAZANAPHTHALENE;1,6-NAPHTHYRIDINE;1,6-Pyridopyridine;PYRIDO[4,3-B]PYRIDINE;Naphthyridine;1,6-Naphthyridine(6CI,7CI,8CI,9CI);1,6-NAPHTHYRIDINE 96+%;1,6-Naphthylridine
• CAS NO: 253-72-5
• Molecular Formula: C₈H₆N₂
• Molecular Weight: 130.15
• Product Categories: PYRIDINE;Heterocycle-Pyridine series
• Mol File: 253-72-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 231-233°C
• Boiling Point: 267.3 °C at 760 mmHg
• Flash Point: 35 °C
• Appearance: /
• Density: 1.183 g/cm³
• Vapor Pressure: 0.0136mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 1,6-NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-NAPHTHYRIDINE(253-72-5)
• EPA Substance Registry System: 1,6-NAPHTHYRIDINE(253-72-5)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 253-72-5(Hazardous Substances Data)

Usage

General Description

1,6-Naphthyridine is a heterocyclic compound with a chemical formula of C8H6N2. It is a colorless, crystalline solid with a melting point of 30-32 °C. This chemical is used in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and functional group compatibility. 1,6-Naphthyridine can also be used as a building block in organic synthesis, particularly in the production of heterocyclic compounds and complex organic molecules. Additionally, it has potential applications in the field of material science and as a ligand in coordination chemistry. Overall, 1,6-Naphthyridine is a valuable chemical with a wide range of potential applications in various industries.

InChI:InChI=1/C8H6N2/c1-2-7-6-9-5-3-8(7)10-4-1/h1-6H

Upstream product

• 99584-24-4 5-hydrazinyl-1,6-naphthyridine 
• 88511-27-7 3-iodopyridin-4-amine 
• 107-18-6 allyl alcohol 
• 533-37-9 2,3-cyclopentenopyridine 
• 90685-58-8 6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 927-63-9 3-dimethylaminoacrolein 
• 504-24-5 4-aminopyridine 
• 56-81-5 glycerol 
• 107-21-1 ethylene glycol 
• 23616-32-2 5-chloro-[1,6]naphthyridine 
• 5860-72-0 7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one 
• 106837-37-0 2-(2-hydroxy-ethyl)-nicotinic acid amide 
• 23616-31-1 1,6-naphthyridine-5(6H)-one 

Downstream Products

• 90781-10-5 6-Benzyl-[1,6]naphthyridin-6-ium 
• 316155-80-3 5-benzyl-5H-[1,6]naphthyridine-6-carboxylic acid ethyl ester 
• 316155-83-6 5-(4-benzyloxy-benzyl)-5H-[1,6]naphthyridine-6-carboxylic acid ethyl ester 
• 316155-92-7 5-(4-hydroxy-benzyl)-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid ethyl ester 
• 316156-00-0 4'-(5,6,7,8-tetrahydro-[1,6]naphthyridin-5-ylmethyl)-biphenyl-4-ylamine 
• 316156-04-4 5-(4'-amino-biphenyl-4-ylmethyl)-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 
• 316155-96-1 5-(4'-nitro-biphenyl-4-ylmethyl)-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid ethyl ester 
• 6052-72-8 5,6,9,10-tetrahydro-4H,8H-pyrido[3,2,1-ij][1,6]naphthyridine 
• 19693-54-0 6-Methyl-1,6-naphthyridin-5-(6H)-on 
• 1133853-53-8 (R)-N-(4-fluorophenyl)-5-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide 
• 1133853-52-7 5-(4-(trifluoromethyl)-phenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 1133853-49-2 ethyl 5-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 
• 1133853-45-8 ethyl 5-(4-(trifluoromethyl)phenyl)-1,6-naphthyridine-6(5H)-carboxylate 
• 75509-73-8 5,6,7,8-tetrahydro-6-(3,4-dimethoxybenzyl)-1,6-naphthyridine 

Relevant articles and documents

Convenient preparation of naphthyridines from halopyridines: Sequential Heck coupling and cyclization

A simple method for the preparation of 1,7-naphthyridine and 1,6-naphthyridine from the corresponding aminopyridine starting materials is presented.

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HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

A one-pot method for the synthesis of naphthyridines via modified friedl?nder reaction

A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a β-dimethylamino or β-alkoxyacrolein derivative. This method is also applicable to 1,6-naphthyridines. Georg Thieme Verlag Stuttgart.