1133891-05-0Relevant articles and documents
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2
Duncton, Matthew A.J.,Piatnitski Chekler, Eugene L.,Katoch-Rouse, Reeti,Sherman, Dan,Wong, Wai C.,Smith II, Leon M.,Kawakami, Joel K.,Kiselyov, Alexander S.,Milligan, Daniel L.,Balagtas, Chris,Hadari, Yaron R.,Wang, Ying,Patel, Sheetal N.,Rolster, Robin L.,Tonra, James R.,Surguladze, David,Mitelman, Stan,Kussie, Paul,Bohlen, Peter,Doody, Jacqueline F.
, p. 731 - 740 (2009)
A series of arylphthalazine derivatives were synthesized and evaluated as antagonists of VEGF receptor II (VEGFR-2). IM-094482 57, which was prepared in two steps from commercially available starting materials, was found to be a potent inhibitor of VEGFR-