1134-82-3

Usage

Uses

Used in Medicinal Chemistry:
2-Benzyl-5-methyl-2H-pyrazol-3-ylamine is used as a potential pharmaceutical agent for its possible biological activity. Its unique structure may contribute to the development of new drugs with therapeutic benefits.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-benzyl-5-methyl-2H-pyrazol-3-ylamine is used as a building block for the synthesis of various pharmaceutical agents. Its properties and reactivity make it a valuable intermediate for the production of other organic compounds, which can be further utilized in drug development.
Used in Organic Compound Production:
2-Benzyl-5-methyl-2H-pyrazol-3-ylamine is also used as an intermediate in the production of other organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of a wide range of organic molecules, contributing to the advancement of organic chemistry and related fields.

InChI:InChI=1/C11H13N3/c1-9-7-11(12)14(13-9)8-10-5-3-2-4-6-10/h2-7H,8,12H2,1H3

Upstream product

• 137968-23-1 1-(Benzylamino)-5-methylpyrazole 
• 34362-22-6 2,3-dichlorobutanenitrile 
• 555-96-4 Benzylhydrazine 
• 1118-61-2 3-Aminocrotononitrile 
• 2469-99-0 Cyanoaceton 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 
• 100-52-7 benzaldehyde 
• 1073-62-7 N-benzylhydrazine hydrochloride 

Downstream Products

• 184172-84-7 5-amino-1-benzyl-3-methyl-4-nitrosopyrazole 
• 1131121-64-6 5-bromo-3-methyl-1-(phenylmethyl)-1H-pyrazolo[3,4-b]pyridine 
• 1620103-05-0 1-benzyl-3-methyl-4-thiocyanato-5-amino-1H-pyrazole 

Relevant academic research and scientific papers

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targets for numerous indications. Previously reported urea containing molecules as GIRK1/2 preferring activators have had significant pharmacokinetic (PK) liabilities. Here we report a novel series of 1H-pyrazolo-5-yl-2-phenylacetamides in an effort to improve upon the PK properties. This series of compounds display nanomolar potency as GIRK1/2 activators with improved brain distribution (rodent Kp > 0.6).

SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

INHIBITORS OF AKT ACTIVITY

Invented are novel substituted pyridine compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

The Boulton-Katritzky rearrangement of isocarboxazid

(Chemical Equation Presented) Isocarboxazid rearranges on heating to 5-acetonyl-2-benzyl-4-hydroxy-1,2,3-triazole in DMF at 150°C, in the ionic liquid, [bmin]HSO4- at 100°C or as a melt at 105°C. This is the first reported example of the Boulton-Katritzky rearrangement of an acyl hydrazide.

Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation

The invention relates to novel compositions for the oxidation dyeing of keratin fibers, comprising at least one specific diaminopyrazole derivative, to the dyeing process using this composition, to novel diaminopyrazole derivatives and to a process for their preparation.

Rearrangement of N-(Alkylamino)azoles in Acid Media: A New Entry to C-Amino-N-substituted Azoles

A ring-opening / ring-closure mechanism for the thermal rearrangement of 1-(alkylamino)pyrazoles into 5-amino-1-alkylpyrazoles in acid medium has been established. 1-(Benzylamino)pyrazoles show a different reactivity, affording bis(5-amino-1-benzyl-4-pyrazolyl)phenylmethanes.The reaction was extended to 1-(alkylamino)indazoles but failed in the case of 1-(alkylamino)-1,2,4-triazoles.

Aminopyrazoles. IV. Pyrazol-3- and 5-amines from 2,3-dihaloalkanenitriles or 3-Chloroacrylonitriles and Hydrazines

2,3-Dihalopropanenitriles and substituted 3-chloropropenenitriles react with hydrazines in basic solution to form either pyrazol-3-amines 4 or pyrazol-5-amines 5 or a mixture of both isomers.