1134099-83-4

Basic information

• Product Name: 2-(4-benzylpiperidin-1-yl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
• CAS NO: 1134099-83-4
• Molecular Weight: 333.433
• Mol File: 1134099-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-benzylpiperidin-1-yl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-benzylpiperidin-1-yl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(1134099-83-4)
• EPA Substance Registry System: 2-(4-benzylpiperidin-1-yl)-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone(1134099-83-4)

Safety Data

• Hazardous Substances Data: 1134099-83-4(Hazardous Substances Data)

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 83393-47-9 2-chloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one 

Relevant articles and documents

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

A combined ligand-based and structure-based approach has previously allowed us to identify NR2B/NMDA receptor antagonists containing indole scaffold. In order to further explore the main structure activity relationships of this class of derivatives we herein report the design, synthesis and biological evaluation of new analogues. Some derivatives demonstrated to produce significant anticonvulsant properties and NMDA antagonism. The most active of them (3d) showed NR2B binding affinity equipotent to that of ifenprodil. These results were also corroborated by computational studies.