113446-38-1Relevant academic research and scientific papers
Highly efficient "on water" catalyst-free nucleophilic addition reactions using difluoroenoxysilanes: Dramatic fluorine effects
Yu, Jin-Sheng,Liu, Yun-Lin,Tang, Jing,Wang, Xin,Zhou, Jian
, p. 9512 - 9516 (2014)
A remarkable fluorine effect on "on water" reactions is reported. The C-FaH-O interactions between suitably fluorinated nucleophiles and the hydrogen-bond network at the phase boundary of oil droplets enable the formation of a unique microstructure to facilitate on water catalyst-free reactions, which are difficult to realize using nonfluorinated substrates. Accordingly, a highly efficient on water, catalyst-free reaction of difluoroenoxysilanes with aldehydes, activated ketones, and isatylidene malononitriles was developed, thus leading to the highly efficient synthesis of a variety of α,α- difluoro-β-hydroxy ketones and quaternary oxindoles. It's on! The C-FaH-O interactions between suitably fluorinated nucleophiles and a hydrogen-bond network at the phase boundary of an oil droplet facilitate "on water" catalyst-free reactions. Accordingly, the title reaction of difluoroenoxysilanes with aldehydes, activated ketones, and isatylidene malononitriles was developed, thus leading to α,α-difluoro-β-hydroxy ketones and quaternary oxindoles.
REACTIONS OF POLYHALOGENO FUNCTIONAL COMPOUNDS WITH METALS AND ELECTROPHILIC REAGENTS. V. REACTION OF TRICHLOROACETOPHENONE WITH ZINC AND ELECTROPHILIC REAGENTS
Shchepin, V. V.,Russkikh, N. Yu.,Rybakova, M. N.,Lapkin, I. I.,Petukhova, I. Yu.
, p. 844 - 847 (2007/10/02)
The reaction of trichloroacetophenone with zinc leads to the production of an intermediate ambident organozinc compound, which reacts with acid chlorides, alkylchlorosilanes, and α-chloro ethers with the preferential formation of O-derivatives of the β,β-
