1134565-38-0

Basic information

• Product Name: (4S,5R)-3-acetyl-4,5-dimethyl-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-2(3H)-one
• Synonyms: (4S,5R)-3-acetyl-4,5-dimethyl-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-2(3H)-one
• CAS NO: 1134565-38-0
• Molecular Weight: 306.445
• Mol File: 1134565-38-0.mol

Chemical Properties

• CAS DataBase Reference: (4S,5R)-3-acetyl-4,5-dimethyl-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-3-acetyl-4,5-dimethyl-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-2(3H)-one(1134565-38-0)
• EPA Substance Registry System: (4S,5R)-3-acetyl-4,5-dimethyl-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-2(3H)-one(1134565-38-0)

Safety Data

• Hazardous Substances Data: 1134565-38-0(Hazardous Substances Data)

Upstream product

• 1134565-40-4 (5R,6S)-6-(2-iodoethyl)-1,5,6-trimethylcyclohex-1-ene 

Downstream Products

• 1134565-72-2 1-[(4S,5R)-4,5-dimethyl-2-oxo-4-{2-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]ethyl}-dihydrofuran-3(2H)-ylidene]ethyl acetate 

Relevant articles and documents

Total synthesis of (+)-neomarinone

The first total synthesis of (+)-neomarinone has been achieved by following a concise and convergent route using methyl (R)-lactate and (R)-3-methylcyclohexanone as chiral building blocks. Key steps of the synthesis are the stereocontrolled formation of the two quaternary stereocenters by diastereoselective 1,4-conjugate addition and enolate alkylation reactions, and the construction of the furanonaphthoquinone skeleton by regioselective Diels-Alder reaction between a 1,3-bis(trimethylsilyloxy)-1,3-diene and a bromoquinone. The synthesis proves the relative and absolute stereochemistry of natural neomarinone.