113474-70-7

Basic information

• Product Name: (S)-(-)-2-hydroxy-6-methoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (+)-tartrate
• CAS NO: 113474-70-7
• Molecular Weight: 428.439
• Mol File: 113474-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(-)-2-hydroxy-6-methoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (+)-tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-hydroxy-6-methoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (+)-tartrate(113474-70-7)
• EPA Substance Registry System: (S)-(-)-2-hydroxy-6-methoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (+)-tartrate(113474-70-7)

Safety Data

• Hazardous Substances Data: 113474-70-7(Hazardous Substances Data)

Upstream product

• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 96947-76-1 (S)-(-)-N-<(ethyl-2-pyrrolidinyl)methyl>-2,6-dimethoxybenzamide 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 87-69-4 L-Tartaric acid 
• 84226-04-0 (-)-BZM 

Relevant articles and documents

Dopamine D-2 receptor imaging radiopharmaceuticals: Synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6 methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

In developing central nervous system (CNS) dopamine D-2 receptor imaging agents, enantiomers, R-(+) and S-(-) isomers, of 3-[125I]iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]d benzamide, [125I]IBZM, were synthesized, and their in vitro binding characteristics were evaluated in rat striatum tissue preparation. The (S)-(-)-[125I]IBZM showed high specific dopamine D-2 receptor binding (K(d) = 0.43 nM, B(max) = 0.48 pmol/mg of protein). Competition data of various ligands for IBZM binding displayed the following rank order of potency: spiperone > (S)-(-)-IBZM > (+)-butaclamol >> (R)-(+)-IBZM > (S)-(-)-BZM > dopamine > ketanserin > SCH23390 >> propranolol. The results indicate that [125I]IBZM binds specifically to the dopamine D-2 receptor with stereospecificity. The [123I][IBZM is potentially useful as an imaging agent for the investigation of dopamine D-2 receptors in humans.