1134809-35-0Relevant academic research and scientific papers
New macrocyclic peptidomimetics containing 5-aminothiophene subunits
Oezbek, Huelya,Lentz, Dieter,Reissig, Hans-Ulrich
supporting information; experimental part, p. 6319 - 6322 (2011/02/21)
The synthesis of a new class of cyclic peptidomimetics containing 5-aminothiophene subunits in their backbone is presented. A modified Gewald reaction was applied as a key step in the synthesis of the thiophene amino acid that was used as a building block
Gewald synthesis of aminothiophene carboxylic acids providing new dipeptide analogues
?zbek, Hülya,Veljkovic, Ivana S.,Reissig, Hans-Ulrich
scheme or table, p. 3145 - 3148 (2009/06/17)
A new multicomponent synthesis of 2-aminothiophene carbocyclic acids 4 by reaction of methyl 2-siloxycyclopropane-carboxylates 1, alkyl cyanoacetates, and elemental sulfur is reported. This version of the Gewald thiophene synthesis rapidly provides a new type of δ-amino acids, which can be considered as dipeptide analogues. Smooth protective-group manipulations allowed regio-and chemoselective couplings with L-phenylalanine derivatives furnishing new tripeptide analogues such as 5 and 8 or products of type 10. Georg Thieme Verlag Stuttgart.
