113484-74-5

Basic information

• Product Name: FMOC-GLY-OSU
• Synonyms: FMOC-GLY-OSU;FMOC-GLYCINE HYDROXYSUCCINIMIDE ESTER;FMOC-GLYCINE N-HYDROXYSUCCINIMIDE ESTER;FMOC-GLYCINE-OSU;N-alpha-(9-Fluorenylmethyloxycarbonyl)-glycine succinimidyl ester;FMOC-GLYCINE HYDROXYSUCCINIMIDESTER;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine 2,5-dioxo-1-pyrrolidinyl ester;N-Fluorenylmethyloxycarbonylglycine N-hydroxysuccinimide ester
• CAS NO: 113484-74-5
• Molecular Formula: C₂₁H₁₈N₂O₆
• Molecular Weight: 394.38
• EINECS: 1533716-785-6
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 113484-74-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 173-175 °C(Solv: ethanol (64-17-5); hexane (110-54-3))
• Appearance: /
• Density: 1.44 g/cm³
• Refractive Index: 1.657
• Storage Temp.: -15°C
• PKA: 9.88±0.46(Predicted)
• CAS DataBase Reference: FMOC-GLY-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLY-OSU(113484-74-5)
• EPA Substance Registry System: FMOC-GLY-OSU(113484-74-5)

Safety Data

• Hazardous Substances Data: 113484-74-5(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C21H18N2O6/c24-18-9-10-19(25)23(18)29-20(26)11-22-21(27)28-12-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17H,9-12H2,(H,22,27)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 

Downstream Products

• 1619923-24-8 (R)-1-(3-(4-(N-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)phenyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperidin-4-yl 2-aminoacetate 
• 35665-38-4 2-[2-{({(9H-fluoren-9-yl)methoxy}carbonyl)amino}acetamido]acetic acid 

Relevant articles and documents

Supramolecular Hydrogels Respond to Ligand-Receptor Interaction

N-(Fluorenyl-9-Methoxycarbonyl) dipeptides form supramolecular hydrogels via hydrogen bonding and hydrophobic interactions. These hydrogels respond to a ligand?receptor interaction as well as to thermal or pH perturbation and also exhibit chiral recognition. Copyright

Site-Specific Incorporation of Multiple Thioamide Substitutions into a Peptide Backbone via Solid Phase Peptide Synthesis

Among various peptide modification strategies, thioamide substitution by replacing the carbonyl oxygen atom of an amide bond with a sulfur atom constitutes an invaluable tool for chemical biology, for use in peptide drug discovery and protein structure-fu

POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO

The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand- targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.