113485-73-7Relevant articles and documents
Antihypertensive phosphate derivatives
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, (2008/06/13)
Antihypertensive phosphate derivatives are described having the following formula: STR1 wherein n is an integer 1 or 2; m is an integer 1 or 2, and the sum of n and m must be 3; X is selected from the group consisting of C1 -C24 branched or straight chain alkoxy and substituted phenoxy wherein the substituents are selected from one or more of the group consisting of C1 -C20 branched or straight chain alkyl, C1 -C20 branched or straight chain alkoxy, halogen, phenyl and substituted phenyl; T is selected from the group consisting of hydrogen and STR2 wherein R1 is selected from the group consisting of hydrogen, C1 -C4 branched or straight chain alkyl, C1 -C4 branched or straight chain alkoxy and C1 -C4 branched or straight chain alkylamino, Q is a bivalent radical selected from the group consisting of --(CH2)p -- and --(CHR)p --, where p is an integer from 2 to 12 and the moiety --(CHR)p -- represents an alkylene chain which is substituted by one or more C1 -C10 alkyl groups or phenyl groups; Z is selected from the group consisting of --+ N(R2)3 and STR3 wherein R2 may be the same or different and is selected from the group consisting of hydrogen and C1 -C4 branched or straight chain alkyl and q is an integer from 4 to 7.
Analogues of Platelet Activating Factor (PAF). 2. Some Modifications of the Glycerine Backbone
Wissner, A.,Schaub, R. E.,Sum, P.-E.,Kohler, C. A.,Goldstein, B. M.
, p. 1181 - 1187 (2007/10/02)
Racemic analogues of platelet activating factor (PAF) that contain a methylene group between the C2 and C3 carbon atoms (39) or between the C1 and C2 carbon atoms (40) have been synthesized.These compounds show reduced platelet aggregation and hypotensive activity as measured against racemic C16 PAF.Compounds in which the C1 carbon atom of PAF is substituted with one or two methyl groups (41 and 42, respectively) or the C3 carbon is substituted with a single methyl group (43) have been synthesized.Platelet aggregation and hypotensive responses producedby these compounds are significantly less than those obtained with racemic C16 PAF.None of the above compounds exhibit a separation of the platelet aggregation and hypotensive activities.