2136-71-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(Hexadecyloxy)ethanol is used as a reagent in the synthesis of anti-HIV alkyl and alkoxyethyl phosphodiester AZT derivatives. Its amphiphilic nature plays a crucial role in the development of these pharmaceutical compounds, enhancing their ability to target and interact with specific biological molecules, thereby contributing to their antiviral activity against HIV.

InChI:InChI=1/C18H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-20-18-16-19/h19H,2-18H2,1H3

Upstream product

• 6068-28-6 tosylate de n-hexadecyle 
• 107-21-1 ethylene glycol 
• 112-82-3 hexadecanyl bromide 
• 58210-01-8 methyl hexadecyloxyacetate 
• 36653-82-4 1-Hexadecanol 
• 75-21-8 oxirane 
• 119980-28-8 1-hexadecyloxy-2-benzyloxyethane 
• 58210-02-9 (Hexadecyloxy)acetic acid 

Downstream Products

• 255906-29-7 [2,3-bis-(2-hexadecyloxy-ethoxy)-propoxymethyl]-benzene 
• 255906-33-3 toluene-4-sulfonic acid 2,3-bis-(2-hexadecyloxy-ethoxy)-propyl ester 
• 97150-20-4 4-hydroxy-N,N,N-trimethyl-8-(phenylmethoxy)-3,5,10-trioxa-4-phosphahexacosan-1-aminium 4-oxide, hydroxide 
• 97150-03-3 <<<1-<(hexadecyloxy)methyl>-2-propenyl>oxy>methyl>-benzene 
• 113485-73-7 4-(hexadecyloxy)-3-(phenylmethoxy)-1-butanol 
• 171364-92-4 toluene-4-sulfonic acid 2-hexadecyloxy-ethyl ester 

Relevant academic research and scientific papers

N4 - hydroxycytidine derivative as well as preparation method and application thereof

The invention relates to N4 - hydroxycytidine derivatives as shown in general formula I. A pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof, and the substituted N4 - hydroxycytidine derivative structure of the structure of Formula I. The pharmaceutical composition is used for preparing medicaments for treating infections such as SARS-CoV, HBV, HCV, H1N1, Ebola and SARS-CoV - 2, can effectively inhibit influenza viruses and SARS-CoV - 2 viruses, and can have the same result on other RNA viruses. The series of compounds can be applied to preparation of anti RNA virus drugs. The medicine is used for preparing a medicine for treating virus infection and is used for preparing a vaccine adjuvant for treating virus infection.

Polycyclic pyridinone compounds and pharmaceutical compositions and uses thereof

The invention discloses a polycyclic pyridone compound as well as a pharmaceutical composition and application thereof, and the polycyclic pyridone compound is shown as a formula (I). The compound can be used for preparing anti-virus infection drugs.

An N4-hydroxycytoside derivative and its preparation method and use

The present invention provides an N4- hydroxycytidine derivative as shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof: 。 The compounds of the present invention have the following significant advantages: (1) the N4-hydroxycytidine compounds and their derivatives have a highly efficient inhibitory activity of RNA-dependent RNA polymerases of RNA viruses; (2) the N4-hydroxycytoside compounds and their derivatives and pharmaceutical compositions are widely used, can be prepared to treat / prevent SARS-CoV, HBV, HCV, H1N1, Ebola or SARS-CoV-2 virus infection disease drugs.

Preparation method of higher fatty alcohol 2-alkoxy ethanol

The invention provides a preparation method of higher fatty alcohol 2-alkoxy ethanol, and relates to the technical field of organic synthesis, higher fatty alcohol and sulfonyl halide are used as raw materials for cascade reaction, the higher fatty alcohol is completely converted into sulfonate under the action of alkali, and then the sulfonate is subjected to phase transfer reaction under the promotion of a phase transfer catalyst (the used phase transfer catalyst comprises quaternary ammonium salt or crown ether), sulfonate directly performs nucleophilic substitution reaction with ethylene glycol, and the reaction temperature is controlled to complete the reaction within half an hour to obtain the corresponding higher fatty alcohol 2-alkoxy ethanol. The method is low in raw material and reagent cost, simple in process operation, small in pollution, high in product yield and purity, and suitable for large-scale preparation.

Containing polyoxyethylene ether hydroxy propyl aniline [...] permanaganate betaine and its preparation method

The invention relates to polyoxyethylene-ether-containing hydroxypropyl anilino carboxylate betaine and a preparation method thereof, and mainly solves the problems in the prior art that an oil-displacement agent containing a surfactant is bad in oil displacement effect and high in use concentration under the oil reservoir conditions of high temperature and high salinity, and alkalis in alkali-surfactant-polymer flooding pollute and damage stratum and oil wells and severely corrode equipment and conveying pipelines. The polyoxyethylene-ether-containing hydroxypropyl anilino carboxylate betaine has the molecular general formula (I) shown in the specification, and in the formula (I), R1 is any one of C15-C39 alkyl and alkenyl, n is 1-10, R2 is any one of C1-C4 alkylidene and hydroxyl-substituted alkylidene. The technical scheme relatively well solves the problems and is applicable to tertiary oil recovery of oil fields.

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

N-Acylethanolamines (NAEs) including N-arachidonoylethanolamine (anandamide) and N-palmitoylethanolamine are endogenous lipid mediators. These molecules are degraded to the corresponding fatty acids and ethanolamine by fatty acid amide hydrolase (FAAH) or NAE-hydrolyzing acid amidase (NAAA). Lipophilic amines, especially pentadecylamine (2c) and tridecyl 2-aminoacetate (11b), were found to exhibit potent NAAA inhibitory activities (IC50 = 5.7 and 11.8 μM), with much weaker effects on FAAH. These simple structures would provide a scaffold for further improvement in NAAA inhibitory activity.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.

Anchor dependency for non-glycerol based cationic lipofectins: Mixed bag of regular and anomalous transfection profiles

Although detailed structure-activity, physicochemical and biophysical investigations in probing the anchor influence in liposomal gene delivery have been reported for glycerol-based transfection lipids, the corresponding investigation for non-glycerol based simple monocationic transfection lipids have not yet been undertaken. Towards this end, herein, we delineate our structure-activity and physicochemical approach in deciphering the anchor dependency in liposomal gene delivery using fifteen new structural analogues (lipids 1-15) of recently reported non-glycerol based monocationic transfection lipids. The C14 analogues in both series 1 (lipids 1-6) and series 2 (lipids 7-15) showed maximum efficiency in transfecting COS-1 and CHO cells. However, the C12 analogue of the ether series (lipid 3) exhibited a seemingly anomalous behavior compared with its transfection efficient C10 and C14 analogues (lipids 2 and 4) in being completely inefficient to transfect both COS-1 and CHO cells. The present structure-activity investigation also convincingly demonstrates that enhancement of transfection efficiencies through incorporation of membrane re-organizing unsaturation elements in the hydrophobic anchor of cationic lipids is not universal but cell dependent. The strength of the interaction of lipids 1-15 with DNA was assessed by their ability to exclude ethidium bromide bound to the DNA. Cationic lipids with long hydrophobic tails were found, in general, to be efficient in excluding EtBr from DNA. Gel to liquid crystalline transition temperatures of the lipids was measured by fluorescence anisotropy measurement technique. In general (lipid 2 being an exception), transfection efficient lipids were found to have their mid transition temperatures at or below physiological temperatures (37°C).

Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions

Quaternary amine-containing ether lipid analogs of the formula are disclosed. R1 represents a hydrophobic group and R2 represents the backbone of the molecule, with the quaternary amine being linked directly to the backbone. Pharmaceutical compositions including these compounds and methods of combating tumors with these compounds are disclosed. Also disclosed is a method of combating viral infections with both these compounds and ET-18-OMe and its analogs.

Synthesis of Hydroxyethyl Ethers from Long Chain Fatty Alcohols

A two-step facile synthesis of mono- and di-β-hydroxyethyl ethers of long chain fatty alcohols starting from alcohols and chloro/bromo acetic esters is described.These compounds, which are otherwise difficult to obtain in pure state, are of great interest as plant groth promoters.