1134925-03-3Relevant articles and documents
Ratiometric fluorescent signaling of small molecule, environmentally sensitive dye conjugates for detecting single-base mutations in DNA
Wang, Chun-Xia,Sato, Yusuke,Kudo, Megumi,Nishizawa, Seiichi,Teramae, Norio
, p. 9481 - 9484 (2012)
Bind it! A ratiometric fluorescent probe based on conjugation of a DNA-binding ligand with an environmentally sensitive dye to probe hydrophobic grooves of the DNA helix was developed. The resulting conjugate ATMND-DBD can bind to an orphan nucleobase opposite an abasic (AP) site with high selectivity and affinity for pyrimidine bases (see figure). Copyright