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1134963-85-1

N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1134963-85-1 Structure

  • Basic information

    1. Product Name: N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide
    2. Synonyms: N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide
    3. CAS NO:1134963-85-1
    4. Molecular Formula:
    5. Molecular Weight: 289.254
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1134963-85-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide(1134963-85-1)
    11. EPA Substance Registry System: N-[2-formyl-4-(trifluoromethoxy)phenyl]pivaloylamide(1134963-85-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1134963-85-1(Hazardous Substances Data)

1134963-85-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1134963-85-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,4,9,6 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1134963-85:
(9*1)+(8*1)+(7*3)+(6*4)+(5*9)+(4*6)+(3*3)+(2*8)+(1*5)=161
161 % 10 = 1
So 1134963-85-1 is a valid CAS Registry Number.

1134963-85-1Relevant articles and documents

Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents

Mancini, Alessandra,Chelini, Alessia,Di Capua, Angela,Castelli, Loretta,Brogi, Simone,Paolino, Marco,Giuliani, Germano,Cappelli, Andrea,Frosini, Maria,Ricci, Lorenzo,Leonelli, Erminia,Giorgi, Gianluca,Giordani, Antonio,Magistretti, Jacopo,Anzini, Maurizio

, p. 614 - 630 (2017)

Neurodegenerative diseases are disorders related to the degeneration of central neurons that gradually lead to various, severe alterations of cognitive and/or motor functions. Currently, for no such diseases does any pharmacological treatment exist able to arrest its progression. Riluzole (1) is a small molecule able to interfere with multiple cellular and molecular mechanisms of neurodegeneration, and is the only approved treatment of amyotrophic lateral sclerosis (ALS), the progression of which proved to significantly slow, thus increasing somewhat average survival. Here we report the synthesis of differently functionalized 4H-3,1-benzothiazine (5–6) and 2H-1,4-benzothiazine (7) series as superior homologues of 1. Biological evaluation demonstrated that amidine 4H-3,1-benzothiazine derivatives 5b-d can reduce glutamate and LDH release in the oxygen/glucose deprivation and reperfusion model (OGD/R) applied to brain slices with a higher potency than 1. Moreover the mentioned compounds significantly reduce glutamate- and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in neuroblastoma cells. In addition, the same compounds limit ROS formation in both neuronal preparations. Finally, 5c proved effective in inhibiting neuronal voltage-dependent Na+and Ca2+-channels, showing a profile comparable with that of 1.

AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES, NOVEL PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES

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Page/Page column 29; 30, (2009/05/29)

The present invention relates to novel amidine, thiourea and guanidine derivatives of appropriately substituted 2-aminobenzothiazoles, 2-amino-3,l-4H-benzothiazines and 3- amino-l,4-3H-benzothiazines, as understood from formula (I), the related pharmaceutically acceptable salts and solvates thereof: Formula (I): and the use of said products and the corresponding pharmaceutical formulations for the treatment of neurodegenerative pathologies such as cerebral ischemia, neurodegeneration induced by cranial trauma, Alzheimer's disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.

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