1135-00-8

Usage

Uses

Used in Plasticizer Applications:
4-N-BUTYLBENZENESULFONAMIDE is used as a plasticizer in various polymer applications due to its low migration and good thermal stability, making it an ideal choice for enhancing the flexibility and workability of plastics.
Used in Food Contact Materials:
4-N-BUTYLBENZENESULFONAMIDE is used as an additive in food contact materials because of its low volatility and leachability, ensuring the safety and integrity of food products during packaging and storage.
Used in Medical Devices:
4-N-BUTYLBENZENESULFONAMIDE is utilized in the manufacturing of medical devices, where its low migration properties and thermal stability contribute to the device's performance and patient safety.
Used as an Intermediate in Chemical Production:
4-N-BUTYLBENZENESULFONAMIDE is used as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes, playing a crucial role in the synthesis of various end products.
Safety Precautions:
It is important to handle and store 4-N-BUTYLBENZENESULFONAMIDE with care, as it may be harmful if swallowed or inhaled and can cause irritation to the eyes and skin. Proper safety measures should be taken during its use and disposal to minimize potential health risks.

InChI:InChI=1/C10H15NO2S/c1-2-3-4-9-5-7-10(8-6-9)14(11,12)13/h5-8H,2-4H2,1H3,(H2,11,12,13)

Upstream product

• 576171-88-5 N-tert-butyl-4-butylbenzenesulfonamide 
• 54997-92-1 4-butylbenzene-1-sulfonyl chloride 
• 104-51-8 1-butylbenzene 

Downstream Products

• 1610050-48-0 C₁₆H₂₈NO₂PS 
• 1025096-61-0 (4-butylbenzene-1-sulfonamido)bisphenylphosphine 
• 1359677-31-8 C₂₂H₂₄NO₂PS 
• 1158247-94-9 N,N'-((9,9-dimethyl-9H-xanthene-4,5-diyl)bis(phenylphosphinediyl))bis(4-butylbenzenesulfonamide) 
• 1438389-71-9 1-benzyloxycarbonyl-4-(R)-tert-butyldimethylsilyloxy-N-(p-butylbenzenesulfonyl)-2-(S)-pyrrolidinecarboxamide 
• 1359677-32-9 C₄H₉C₆H₄SO₂NPH(C₆H₅)C₆H₄OCH₃ 
• 1158247-92-7 C₂₃H₂₆NO₃PS 
• 1359754-34-9 C₅₄H₄₈NO₆PS 
• 1158651-59-2 C₅₄H₄₈NO₆PS 

Relevant academic research and scientific papers

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

Boron trichloride as an efficient and selective agent for deprotection of tert-butyl aryl sulfonamides

A fast, mild and selective method for deprotection of tert-butyl aryl sulfonamides utilizing BCl3 as deprotection reagent has been developed. A variety of tert-butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The method does not cleave methoxy groups and prevents incorporation of tert-butyl groups onto electron-rich aromatic rings.

Catalytic Properties of Carbonyl Reductase from Rabbit Kidney for Acetohexamide and Its Analogs

Analogs submitted by ethyl, n-propyl, n-butyl, and isopropyl groups instead of methyl group adjacent to a ketone group of acetohexamide were synthesized and the structural requirements of carbonyl reductase from rabbit kidney for these analogs were kineti

Process for the production of benzenesulfonamides

Process comprises the combination of two steps of interacting a R-benzene, sulfuric acid and phosphorus oxychloride to obtain 4-R-benzenesulfonyl chloride and amidating said sulfonyl chloride to produce 4-R-benzenesulfonamide.