54997-92-1

Usage

Uses

Used in Pharmaceutical Industry:
4-N-Butylbenzenesulfonyl chloride is used as an intermediate in the synthesis of pharmaceuticals for its ability to introduce sulfonyl chlorides into organic molecules, which can enhance the properties and effectiveness of the final drug products.
Used in Agrochemical Industry:
In the agrochemical industry, 4-N-butylbenzenesulfonyl chloride serves as an intermediate in the production of various agrochemicals, contributing to the development of compounds with specific pesticidal or herbicidal properties.
Used in Dye Production:
4-N-Butylbenzenesulfonyl chloride is used as a key component in the synthesis of dyes, where its reactivity and structural features enable the creation of dyes with desired color and stability characteristics.
Used in Polymer Synthesis:
4-N-BUTYLBENZENESULFONYL CHLORIDE is utilized in the production of polymers, where its sulfonyl chloride group can be incorporated into the polymer backbone, imparting specific properties such as solubility, thermal stability, or chemical resistance.
Used in Organic Synthesis as a Key Reagent:
4-N-Butylbenzenesulfonyl chloride is used as a key reagent in organic synthesis due to its reactivity in introducing sulfonyl chlorides into organic molecules, facilitating the formation of new chemical bonds and the synthesis of diverse organic compounds with specific properties.

InChI:InChI=1/C10H13ClO2S/c1-2-3-4-9-5-7-10(8-6-9)14(11,12)13/h5-8H,2-4H2,1H3

Upstream product

• 104-51-8 1-butylbenzene 

Downstream Products

• 25111-61-9 3-(4-Butyl-benzolsulfonylamino)-propionsaeurenitril 
• 86887-27-6 4-Butyl-N-(4-chloro-3-nitro-phenyl)-benzenesulfonamide 
• 956102-17-3 7-(4-butyl-benzenesulfonylamino)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester 
• 784137-02-6 4-butyl-N-(2,3-dihydro-1H-isoindol-5-yl)-benzenesulfonamide 
• 583025-23-4 4-butyl-N-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-benzenesulfonamide 
• 583025-17-6 4-butyl-N-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-benzenesulfonamide 

Relevant academic research and scientific papers

Development of sulfonamide AKT PH domain inhibitors

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon resonance-based competitive binding assay. Cellular activity was determined by means of an assay for pAKT production and a cell killing assay using BxPC-3 cells. The most active compounds in the set are lipophilic and possess an aliphatic chain of the proper length. Results were interpreted with the aid of computational modeling. This paper represents the first structure-activity relationship (SAR) study of a large family of AKT PH domain inhibitors. Information obtained will be used in the design of the next generation of inhibitors of AKT PH domain function.

SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME

Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

Catalytic Properties of Carbonyl Reductase from Rabbit Kidney for Acetohexamide and Its Analogs

Analogs submitted by ethyl, n-propyl, n-butyl, and isopropyl groups instead of methyl group adjacent to a ketone group of acetohexamide were synthesized and the structural requirements of carbonyl reductase from rabbit kidney for these analogs were kineti