1135021-79-2

Basic information

• Product Name: (2-chloro-5-nitrophenyl)methanamine hydrochloride
• Synonyms: (2-chloro-5-nitrophenyl)methanamine hydrochloride
• CAS NO: 1135021-79-2
• Molecular Weight: 223.059
• Mol File: 1135021-79-2.mol

Chemical Properties

• CAS DataBase Reference: (2-chloro-5-nitrophenyl)methanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-5-nitrophenyl)methanamine hydrochloride(1135021-79-2)
• EPA Substance Registry System: (2-chloro-5-nitrophenyl)methanamine hydrochloride(1135021-79-2)

Safety Data

• Hazardous Substances Data: 1135021-79-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-chloro-5-nitrophenyl)methanamine hydrochloride is used as an intermediate in the production of certain medicines. Its role in the synthesis process is crucial for creating the active ingredients of various pharmaceuticals, contributing to the development of new treatments and therapies.
Used in Agricultural Industry:
(2-chloro-5-nitrophenyl)methanamine hydrochloride also serves as an intermediate in the production of pesticides. (2-chloro-5-nitrophenyl)methanamine hydrochloride plays a significant part in the creation of substances that help protect crops from pests and diseases, ensuring food security and crop yield.
Used in Research and Development:
Due to its unique chemical properties, (2-chloro-5-nitrophenyl)methanamine hydrochloride is used as a valuable chemical in various research and industrial applications. It aids scientists and researchers in exploring new chemical reactions and developing innovative products.
Safety and Handling:
It is important to handle (2-chloro-5-nitrophenyl)methanamine hydrochloride with caution as it may pose health and environmental hazards if not used and disposed of properly. Proper safety measures and disposal protocols should be followed to mitigate any risks associated with (2-chloro-5-nitrophenyl)methanamine hydrochloride.

Upstream product

• 16588-15-1 2-chloro-5-nitro-benzamide 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 

Relevant articles and documents

Reactions of 4,5-dihydro-1,4-benzothiazepin-3(2H)-one 1,1-dioxide and 1,5-dihydro-4,1-benzothiazepin-2(3H)-one 4,4-dioxide derivatives with vilsmeier reagent and DMFDMA

The regioselectivity of the interaction between isomeric 4,5-dihydro-1,4-benzothiazepin-3(2H)-one 1,1-dioxide and 1,5-dihydro-4,1- benzothiazepin-2(3H)-one 4,4-dioxide derivatives with the Vilsmeier reagent and DMFDMA (N,N-dimethylformamide dimethylacetal

META-DIAMIDE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS

Disclosed are compounds of Formula (1), N-oxides, and salts thereof, wherein Q, X, Y, A1, A2, L, R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.

N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

Isoniazid (INH) remains one of the cornerstones of antitubercular chemotherapy for drug-sensitive strains of M.tuberculosis bacteria. However, the increasing prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains containing mutations in the KatG enzyme, which is responsible for the activation of INH into its antitubercular form, have rendered this drug of little or no use in many cases of drug-resistant tuberculosis. Presented herein is a novel family of antitubercular direct NADH-dependent 2-trans enoyl-acyl carrier protein reductase (InhA) inhibitors based on an N-benzyl-4-((heteroaryl)methyl)benzamide template; unlike INH, these do not require prior activation by KatG. Given their direct InhA target engagement, these compounds should be able to circumvent KatG-related resistance in the clinic. The lead molecules were shown to be potent inhibitors of InhA and showed activity against M.tuberculosis bacteria. This new family of inhibitors was found to be chemically tractable, as exemplified by the facile synthesis of analogues and the establishment of structure-activity relationships. Furthermore, a co-crystal structure of the initial hit with the enzyme is disclosed, providing valuable information toward the design of new InhA inhibitors for the treatment of MDR/XDR tuberculosis.