16588-15-1

Usage

Uses

Used in Organic Synthesis:
2-Chloro-5-Nitrobenzamide is used as a key intermediate in the synthesis of various organic compounds. Its presence in the benzamide family and its structural features make it a valuable component in the production of a wide range of chemicals.
Used in Scientific Research:
In the field of scientific research, 2-Chloro-5-Nitrobenzamide is employed as a versatile compound for studying chemical reactions and processes. Its unique structure and reactivity contribute to the understanding of organic synthesis and the development of new chemical entities.
Used in Industrial Applications:
Although the specific industrial applications may vary, 2-Chloro-5-Nitrobenzamide is utilized in certain industries as a chemical intermediate. Its role in these applications is typically dependent on the specific synthesis pathways it is involved in, highlighting its importance in the production of various industrial chemicals.
Used in Pharmaceutical Contexts:
The potential applications of 2-Chloro-5-Nitrobenzamide in pharmaceutical contexts are subject to the specific pathways in the synthesis processes it is involved in. Its use in this field is primarily as a chemical intermediate, contributing to the development of new pharmaceutical compounds and therapeutic agents.

InChI:InChI=1/C7H5ClN2O3/c8-6-2-1-4(10(12)13)3-5(6)7(9)11/h1-3H,(H2,9,11)

Upstream product

• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 104599-67-9 4-<(2-Chlor-5-nitrobenzoyl)amino>-3-penten-2-on 
• 7697-37-2 nitric acid 
• 609-66-5 2-chlorobenzamide 
• 873-32-5 2-Chlorobenzonitrile 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 118-91-2 ortho-chlorobenzoic acid 
• 95-51-2 o-chloroaniline 

Downstream Products

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 96-97-9 5-nitrosalicylic acid 
• 16588-07-1 2-anilino-5-nitro-benzoic acid amide 
• 857948-79-9 2-(4-acetylamino-phenylsulfanyl)-5-nitro-benzoic acid amide 
• 117821-78-0 2-Cyclohexylsulfanyl-5-nitro-benzamide 
• 136146-73-1 3-amino-7-nitro-4-phenyl-1(2H)isoquinoline 
• 83909-60-8 2-Cyclohexylamino-5-nitro-benzamide 
• 83909-61-9 5-Nitro-2-p-tolylamino-benzamide 
• 16588-10-6 2-(4-Methoxy-phenylamino)-5-nitro-benzamide 
• 83909-58-4 2-Dibutylamino-5-nitro-benzamide 
• 117821-49-5 5-Nitro-2-phenylsulfanyl-benzamide 
• 83909-62-0 2-(2-Diethylamino-ethylamino)-5-nitro-benzamide 
• 30456-14-5 2-methylamino-5-nitro-benzoic acid amide 

Relevant academic research and scientific papers

NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS

Certain 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

Isothiazolones

Isothiazolones having the general structure STR1 where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Arylthio compounds

Antibacterial and antiviral phenylthiols and dithiobisbenzamides have the formula STR1 where n is 1 or 2, Y is hydrogen when n is 1, and a single bond when n is 2; and R1 and R11 are substituent groups, R4 is hydrogen or alkyl, and Z is hydrogen, alkyl, cycloalkyl or sulfamoylphenyl.

Chromogenic thiol indicators based on an isobenzothiazolone ring system

Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: STR1 where R1, R2 and R3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.

A Mild and Convenient Oxidation of Aryl Nitriles to Aryl Amides by Aqueous Sodium Perborate

A series of benzonitriles has been reacted with sodium perborate in water and a cosolvent to produce the corresponding amides in good yield.The procedure is a mild and convenient alternative for the synthesis of aryl amides.

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.