16588-15-1

Basic information

• Product Name: 2-CHLORO-5-NITROBENZAMIDE
• Synonyms: LABOTEST-BB LT01147853;2-CHLORO-5-NITROBENZAMIDE;2-Chloro-5-nitrobenzamide 97%;3-Carbamoyl-4-chloronitrobenzene;3-Carbamoyl-4-chloronitrobenzene, 3-(Aminocarbonyl)-4-chloronitrobenzene
• CAS NO: 16588-15-1
• Molecular Formula: C₇H₅ClN₂O₃
• Molecular Weight: 200.58
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 16588-15-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 178 °C
• Boiling Point: 299 °C at 760 mmHg
• Flash Point: 134.6 °C
• Appearance: /
• Density: 1.52 g/cm³
• Vapor Pressure: 0.00122mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.23±0.50(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITROBENZAMIDE(16588-15-1)
• EPA Substance Registry System: 2-CHLORO-5-NITROBENZAMIDE(16588-15-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 16588-15-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-Nitrobenzamide is a potent and productive chemical compound classified under the benzamide family. Structurally, it is characterized by a benzene ring that carries a nitro group (-NO2), an amide group (-CONH2), and a chlorine atom at the 2nd, 5th and 3rd positions respectively. This organic compound is used widely in scientific research, predominantly in the field of organic synthesis because it's a beneficial intermediate in the production of numerous other chemicals. Being a compound of nitrobenzene, its handling and use require careful adherence to safety procedures due to potential toxicity hazards. The precise influence or applications of 2-Chloro-5-Nitrobenzamide in industrial or pharmaceutical contexts can vary, typically dependent on the specific pathways in the synthesis processes it's involved in.

InChI:InChI=1/C7H5ClN2O3/c8-6-2-1-4(10(12)13)3-5(6)7(9)11/h1-3H,(H2,9,11)

Upstream product

• 104599-67-9 4-<(2-Chlor-5-nitrobenzoyl)amino>-3-penten-2-on 
• 7697-37-2 nitric acid 
• 609-66-5 2-chlorobenzamide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 95-51-2 o-chloroaniline 
• 873-32-5 2-Chlorobenzonitrile 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 

Downstream Products

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 96-97-9 5-nitrosalicylic acid 
• 16588-07-1 2-anilino-5-nitro-benzoic acid amide 
• 857948-79-9 2-(4-acetylamino-phenylsulfanyl)-5-nitro-benzoic acid amide 
• 117821-78-0 2-Cyclohexylsulfanyl-5-nitro-benzamide 
• 136146-73-1 3-amino-7-nitro-4-phenyl-1(2H)isoquinoline 
• 83909-60-8 2-Cyclohexylamino-5-nitro-benzamide 
• 83909-61-9 5-Nitro-2-p-tolylamino-benzamide 
• 16588-10-6 2-(4-Methoxy-phenylamino)-5-nitro-benzamide 
• 83909-58-4 2-Dibutylamino-5-nitro-benzamide 
• 117821-49-5 5-Nitro-2-phenylsulfanyl-benzamide 
• 83909-62-0 2-(2-Diethylamino-ethylamino)-5-nitro-benzamide 
• 30456-14-5 2-methylamino-5-nitro-benzoic acid amide 

Relevant articles and documents

NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS

Certain 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents.

Isothiazolones

Isothiazolones having the general structure STR1 where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R1 and R2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Chromogenic thiol indicators based on an isobenzothiazolone ring system

Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: STR1 where R1, R2 and R3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.