1135312-06-9

Usage

General Description

(R)-2,2,2-trifluoro-1-(3'-fluorophenyl)ethanol is a chemical compound with the molecular formula C8H7F4O. It is a chiral molecule, meaning it has a non-superimposable mirror image, and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. (R)-2,2,2-trifluoro-1-(3'-fluorophenyl)ethanol is a fluorinated alcohol, containing a trifluoromethyl group and a fluorophenyl group. Its unique structure and properties make it useful for the production of pharmaceuticals and other fine chemicals. Additionally, fluorinated compounds are often favored in medicinal chemistry due to their potential for improving drug properties such as metabolic stability and bioavailability.

Upstream product

• 97-72-3 2-Methylpropionic anhydride 
• 81577-10-8 2,2,2-trifluoro-1-(3'-fluorophenyl)ethanol 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 456-48-4 3-Fluorobenzaldehyde 
• 708-64-5 2,2,2,3'-tetrafluoroacetophenone 
• 557-20-0 diethylzinc 

Relevant academic research and scientific papers

Chemo- and Enantioselective Addition and β-Hydrogen Transfer Reduction of Carbonyl Compounds with Diethylzinc Reagent in One Pot Catalyzed by a Single Chiral Organometallic Catalyst

Using a single chiral phosphoramide-Zn(II) complex as the catalyst, the asymmetric β-H transfer reduction of aromatic α-trifluoromethyl ketones and enantioselective addition of aromatic aldehydes with Et2Zn in one pot were successfully realized, affording the corresponding additive products of secondary alcohols in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee) and the reduction products of α-trifluoromethyl alcohols in good to excellent yields with up to 77% ee.

The enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading

A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

Nonenzymatic kinetic resolution of racemic 2,2,2-trifluoro-1-aryl ethanol via enantioselective acylation

Kinetic resolution of a series of 2,2,2-trifluoro-1-aryl ethanol with (R)-benzotetramisole as the catalyst has been investigated. The result showed that when the aryl group in the substrate was a phenyl (or a phenyl substituted by an electron-donating group) or a naphthyl (an extended phenyl) group, the system could give an s value higher than 20. Preparative KR examples demonstrated the applicability of this method in the preparation of some of enantiomerically pure 2,2,2-trifluoro-1-aryl ethanol or 2,2,2-trifluoro-1-aryl-ethyl iso-butyrate.