113546-63-7

Basic information

• Product Name: (BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE
• Synonyms: 2-(Benzo[d]oxazol-2-ylthio)acetohydrazide
• CAS NO: 113546-63-7
• Molecular Formula: C₉H₉N₃O₂S
• Molecular Weight: 223.25
• Mol File: 113546-63-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.44g/cm³
• Refractive Index: 1.691
• CAS DataBase Reference: (BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE(113546-63-7)
• EPA Substance Registry System: (BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE(113546-63-7)

Safety Data

• Hazardous Substances Data: 113546-63-7(Hazardous Substances Data)

Usage

General Description

(BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE is a chemical compound with the molecular formula C10H10N2O2S. It is a hydrazide derivative of (benzooxazol-2-ylsulfanyl)acetic acid, which is used as a precursor in organic synthesis. (BENZOOXAZOL-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE is a potential starting material for the synthesis of various pharmaceuticals and agrochemicals. Its properties and reactivity make it a valuable component in the development of new chemical compounds and materials. Additionally, it has potential applications in the fields of medicinal chemistry and biotechnology.

InChI:InChI=1/C9H9N3O2S/c10-12-8(13)5-15-9-11-6-3-1-2-4-7(6)14-9/h1-4H,5,10H2,(H,12,13)

Upstream product

• 95-55-6 2-amino-phenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 73824-26-7 methyl (2-benzoxazolylthio)acetate 
• 73824-25-6 benzoxazol-2'-yl-mercaptoacetic acid ethyl ester 

Downstream Products

• 140935-60-0 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(4-hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-58-6 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-52-0 2-(Benzooxazol-2-ylsulfanyl)-N-{2-methyl-4-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-54-2 2-(Benzooxazol-2-ylsulfanyl)-N-{2-methyl-4-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-59-7 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(2-chloro-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-57-5 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-56-4 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 140935-53-1 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(4-hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-acetamide 
• 159278-82-7 2-(benzoxazolylthio)acetylhydrazone of benzaldehyde 
• 159278-84-9 2-(benzoxazolylthio)acetylhydrazone of p-hydroxybenzaldehyde 
• 159278-86-1 2-(benzoxazolylthio)acetylhydrazone of p-methoxybenzaldehyde 
• 1430812-57-9 2-(1,3-benzoxazol-2-ylsulfanyl)-N'-[(E)-{3-[4-(methylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene]acetohydrazide 
• 1430812-56-8 2-(1,3-benzoxazol-2-ylsulfanyl)-N'-{(E)-[3-(2,4-dichlorophenyl)-1H-pyrazol-4-yl] methylidene}acetohydrazide 
• 1430813-49-2 2-(1,3-benzoxazol-2-ylsulfanyl)-N'-[(E)-(3-biphenyl-1H-pyrazol-4-yl)methylidene]acetohydrazide 

Relevant articles and documents

Immobilization and release studies of triazole derivatives from grafted copolymer based on gellan-carrying betaine units

New polymer-bioactive compound systems were obtained by immobilization of triazole derivatives onto grafted copolymers and grafted copolymers carrying betaine units based on gellan and N-vinylimidazole. For preparation of bioactive compound, two new types of heterocyclic thio-derivatives with different substituents were combined in a single molecule to increase the selectivity of the biological action. The 5-aryl-amino-1,3,4 thiadiazole and 5-mercapto-1,2,4-triazole derivatives, each containing 2-mercapto-benzoxazole nucleus, were prepared by an intramolecular cyclization of thiosemicarbazides-1,4 disubstituted in acidic and basic medium. The structures of the new bioactive compounds were confirmed by elemental and spectral analysis (FT-IR and1H-NMR). The antimicrobial activity of 1,3,4 thiadiazoles and 1,2,4 triazoles was tested on gram-positive and gram-negative bacteria. The triazole compound was chosen to be immobilized onto polymeric particles by adsorption. The Langmuir, Freundlich, and Dubinin–Radushkevich adsorption isotherm were used to describe the adsorption equilibrium. Also, the pseudo-first and pseudo-second models were used to elucidate the adsorption mechanism of triazole onto grafted copolymer based on N-vinylimidazole and gellan (PG copolymer) and grafted copolymers carrying betaine units (PGB1 copolymer). In vitro release studies have shown that the release mechanism of triazole from PG and PGB1 copolymers is characteristic of an anomalous transport mechanism.

Binding characterization, synthesis and biological evaluation of RXRα antagonists targeting the coactivator binding site

Previously we identified the first retinoid X receptor-alpha (RXRα) modulators that regulate the RXRα biological function via binding to the coregulator-binding site. Here we report the characterization of the interactions between the hit molecule and RXRα through computational modeling, mutagenesis, SAR and biological evaluation. In addition, we reported studies of additional new compounds and identified a molecule that mediated the NF-κB pathway by inhibiting the TNFα-induced IκBα degradation and p65 nuclear translocation.

Polymer conjugates with potential biological activity based on new derivatives of 2-mercaptobenzoxazole-synthesis and characterization

New potentially biologically active compounds derived from 2-mercapto-benzoxazole were synthesized and coupled on polymeric support of poly (maleic anhydride-alt-vinyl acetate) for the preparation of polymer-drug conjugates with controlled drug release. All compounds were characterized by elemental and spectroscopy (FT-IR, 1H-NMR) analysis. The toxicological tests recommend the products for further laboratory screening. [Figure not available: see fulltext.]