113549-10-3

Basic information

• Product Name: 5-BROMO-3,3-(ETHYLENEDITHIO)-1,3-DIHYDRO-INDOLE-2-ONE
• Synonyms: 5-BROMO-3,3-(ETHYLENEDITHIO)-1,3-DIHYDRO-INDOLE-2-ONE
• CAS NO: 113549-10-3
• Molecular Formula: C10H8BrNOS2
• Molecular Weight: 302.21062
• Mol File: 113549-10-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 195-196 °C(Solv: ethanol (64-17-5))
• Boiling Point: 510.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.84±0.1 g/cm3(Predicted)
• PKA: 11.82±0.20(Predicted)
• CAS DataBase Reference: 5-BROMO-3,3-(ETHYLENEDITHIO)-1,3-DIHYDRO-INDOLE-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3,3-(ETHYLENEDITHIO)-1,3-DIHYDRO-INDOLE-2-ONE(113549-10-3)
• EPA Substance Registry System: 5-BROMO-3,3-(ETHYLENEDITHIO)-1,3-DIHYDRO-INDOLE-2-ONE(113549-10-3)

Safety Data

• Hazardous Substances Data: 113549-10-3(Hazardous Substances Data)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 540-63-6 ethane-1,2-dithiol 

Relevant articles and documents

Potential anticonvulsants. 11. Synthesis and anticonvulsant activity of spiro[1,3-dioxolane-2,3'-indolin]-2'-ones and structural analogues

A number of spiro[1,3-dioxolane-2,3'-indolin]-2'-ones were synthesized and tested for anticonvulsant activity in the maximal electroshock seizure (MES) and pentylenetetrazole seizure threshold (sc-Met) tests. 5'-Chlorospiro[1,3-dioxolane-2,3'-indolin]-2'-one was the most active compound in the MES test and had ED50 = 27.97 mg/kg. Structural analogues spiro[1,3-dioxane-2,3'-indolin]-2'-one, spiro[1,3-dithiolane-2,3'-indolin]-2'-one, spiro[indoline-3,2'-[1,3]-oxathiolan]-2-one, and 3,3-dimethoxyindolin-2-one were also evaluated for anticonvulsant activity. Almost all compounds submitted for screening exhibited the ability to protect mice against electrically and chemically induced seizures. The ED50 and TD50 values for some of the title compounds are reported. Anticonvulsant screenings were carried out through NINCDS, NIH.