1136-21-6Relevant articles and documents
Characterization of a novel polysaccharide with anti-colon cancer activity from Lactobacillus helveticus MB2-1
Li, Wei,Tang, Weizhi,Ji, Juan,Xia, Xiudong,Rui, Xin,Chen, Xiaohong,Jiang, Mei,Zhou, Jianzhong,Dong, Mingsheng
, p. 6 - 14 (2015/05/13)
The present study aimed at investigating the potential anti-colon cancer activity of three purified exopolysaccharides fractions (LHEPS-1, LHEPS-2 and LHEPS-3) from the Lactobacillus helveticus MB2-1. The experimental evidence showed that LHEPS-1 significantly inhibited cell proliferation of human colon cancer Caco-2 cells in both time- and concentration-dependent manners. In contrast, no significant improvements of the inhibitory effects of LHEPS-2 and LHEPS-3 on Caco-2 cells were observed with increasing sample concentrations or prolonged incubation time. Furthermore, the structure of LHEPS-1 was elucidated using methylated analysis, gas chromatography-mass spectroscopy (GC-MS) and nuclear magnetic resonance spectroscopy (NMR), including one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR). Results indicated that the LHEPS-1 consisted of a decasaccharide repeating unit with the following structure (n≈122): Our results suggested that the LHEPS-1 produced by L. helveticus MB2-1 might be suitable for using as natural anti-colon cancer drugs and functional foods ingredients.
Flavonol glycosides from the leaves of Sterculia urens roxb
Khatoon,Khabiruddin,Asif,Ansari
, p. 287 - 288 (2007/10/02)
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CLEAVAGE OF INTERGLYCOSIDIC LINKAGES IN PER(TRIMETHYLSILYL)ATED AND PERMETHYLATED CARBOHYDRATES WITH IODOTRIMETHYLSILANE
Honda, Susumu,Ichii, Tsunehiko,Kakehi, Kazuaki
, p. 95 - 104 (2007/10/02)
Iodotrimethylsilane in carbon tetrachloride cleaves interglycosidic linkages in per(trimethylsilyl)ated disaccharides to give iodinolysis products that may be readily hydrolyzed to component monosaccharides.The cleavage rate is dependent on the type of interglycosidic linkage, and is in the order (1->4)2)3)6) for derivatives of β-linked glucobioses.This iodinolysis reagent is more reactive toward interglycosidic linkages in permethylated carbohydrates; all of the linkages in the permethylated derivatives examined were completely cleaved, irrespective of linkage type.Iodinolysis with iodotrimethylsilane, followed by treatment of the products with water, offers a rapid and mild method for hydrolysis of permethylated carbohydrates.