1136153-56-4Relevant articles and documents
Stereoretentive Addition of N-tert-Butylsulfonyl-α-Amido Silanes to Aldehydes, Ketones, α,β-Unsaturated Esters, and Imines
Mita, Tsuyoshi,Saito, Keisuke,Sugawara, Masumi,Sato, Yoshihiro
, p. 1528 - 1531 (2016)
Enantioenriched N-tert-butylsulfonyl-α-amido silanes were successfully reacted with aldehydes, ketones, imines, and α,β-unsaturated esters in the presence of a sub-stoichiometric amount of CsF (0.5 equiv) in 1,2-dimethoxyethane (DME) at -20 °C to afford the corresponding coupling products with up to 89 % enantiospecificity in a retentive manner. Keep your cool! Enantioenriched N-tert-butylsulfonyl-α-amido silanes were successfully reacted with aldehydes, ketones, imines, and α,β-unsaturated esters in the presence of a sub-stoichiometric amount of CsF (0.5 equiv) in 1,2-dimethoxyethane (DME) at -20 °C to afford the corresponding coupling products with up to 89 % enantiospecificity in a retentive manner.
Stereocontrolled synthesis of β-amino alcohols from lithiated aziridines and boronic esters
Schmidt, Frank,Keller, Florian,Vedrenne, Emeline,Aggarwal, Varinder K.
supporting information; experimental part, p. 1149 - 1152 (2009/06/20)
(Chemical Equation Presented) β-Amino alcohols have been prepared with high selectivity by the addition of lithiated aziridines to boronic esters. The regioselectivity of lithiation for aryl aziridines is sensitive to the reaction conditions and to the ba