113619-13-9Relevant academic research and scientific papers
Process development for a large scale stereoselective synthesis of (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene, a key intermediate of a selective estrogen receptor modulator
Cann, Reginald O.,Waltermire, Robert E.,Chung, Jihchin,Oberholzer, Matthew,Kasparec, Jiri,Ye, Yun K.,Wethman, Robert
, p. 1147 - 1152 (2010)
Two efficient large scale syntheses of (Z)-(1-bromobut-1-ene-1,2-diyl) dibenzene are described. The first is a three-step synthetic sequence from trimethyl(phenylethynyl)silane in 63% overall yield. The key transformations involved the stereospecific carb
Highly Stereoselective Access to an (E)-Vinyl Bromide from an Aryl Ketone Leads to Short Syntheses of (Z)-Tamoxifen and Important Substituted Derivatives
Potter, Gerard A.,McCague, Raymond
, p. 6184 - 6187 (2007/10/02)
The enol triflate derived from a 1-(4-alkoxyphenyl)-2-phenyl-1-butanone is unstable, fragmenting to a vinyl cation that can be trapped by bromide ion.The E isomer of the vinyl bromide which is formed in preference (20:1) gave, upon palladium-catalyzed cou
