113680-58-3Relevant academic research and scientific papers
An Alternative Route to 2-Bromo- and 2-Iodo-estradiols from Estradiol
Pert, Derek J.,Ridley, Damon D.
, p. 303 - 309 (2007/10/02)
Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17β-bis(methoxymethyl) ether or the 3-methoxymethyl ether derivative.Treatment of either of these protected estradiols with s-butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo- or 2-iodo-estradiol.
