1137486-80-6

Basic information

• Product Name: 1,3,7-trimethyl-8-(p-fluorophenyl)-xanthine
• Synonyms: 1,3,7-trimethyl-8-(p-fluorophenyl)-xanthine
• CAS NO: 1137486-80-6
• Molecular Weight: 295.301
• Mol File: 1137486-80-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3,7-trimethyl-8-(p-fluorophenyl)-xanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,7-trimethyl-8-(p-fluorophenyl)-xanthine(1137486-80-6)
• EPA Substance Registry System: 1,3,7-trimethyl-8-(p-fluorophenyl)-xanthine(1137486-80-6)

Safety Data

• Hazardous Substances Data: 1137486-80-6(Hazardous Substances Data)

Upstream product

• 58-08-2 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 
• 873-74-5 4-Aminobenzonitrile 
• 3058-39-7 4-iodobenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 

Relevant articles and documents

Smooth Metal-Free Photoinduced Preparation of Valuable 8-Arylxanthines

A set of 8-arylxanthines was prepared under metal-free conditions and in aqueous solvents from arylazo sulfones and caffeine or theophylline. Notably, the process took place by simply exposing the reaction vessel to visible or solar light, and unreacted xanthine could be easily recovered during the purification step.

Direct arylation of n-heteroarenes with aryldiazonium salts by photoredox catalysis in water

A highly effective visible light-promoted "radical-type" coupling of N-heteroarenes with aryldiazonium salts in water has been developed. The reaction proceeds at room temperature with [Ru(bpy)3]Cl 2×6 H2O as a photosensit

Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst

A new palladium-catalyzed methodology was developed for the direct C-arylation of azoles with a broad spectrum of aryl bromides without the presence of phosphines, the aid of CuI, or other metal additives by using pivalic acid as a cocatalyst. The method also allowed the direct C-arylation of the N-heterocycle N-oxides, and to a lesser degree, the perfluoroaromatics. It was also found that the method can not only be applied to the synthesis of 8-aryl-substituted caffeines, but also 8-arylated theophyllines and theobromines. The result showed thatthe method can tolerate an array of functional groups including ester, nitrile, nitro, aldehyde, methoxy, trifluoromethyl, fluoro, and chloro substituents, and can found its applications in a number of fields such as synthetic and medicinal chemistry both in industry and in academia.