113767-64-9Relevant academic research and scientific papers
An alternative route to protected aldols: Cobalt-catalyzed hydroformylation of epoxides and in situ protection of β-hydroxyaldehydes by HC(OMe) 3
Nakano, Koji,Katayama, Masaya,Ishihara, Shinjiro,Hiyama, Tamejiro,Nozaki, Kyoko
, p. 1367 - 1370 (2007/10/03)
A wide range of epoxides were efficiently converted to protected aldols by hydroformylation-acetalization using Co2(CO)8 as a catalyst in trimethyl orthoformate. The formylation of terminal epoxides was regioselective for the terminal position, and (S)-1-benzyloxy-2,3-epoxypropane was transformed into (R)-1-benzyloxy-4,4-dimethoxybutan-2-ol with retention of the configuration.
New one carbon homologation reagents utilizing electrochemical oxidation of organosilicon compounds
Yoshida,Matsunaga,Murata,Isoe
, p. 615 - 624 (2007/10/02)
Phenylthio(trimethylsilyl)methane, phenylthiobis(trimethylsilyl)methane, methoxy(trimethylsilyl)-methane, and methoxybis(trimethylsilyl)methane are deprotonated and the resulting anions are alkylated with electrophiles such as organic halides. The alkylation products are readily converted into the corresponding dimethyl acetals or methyl esters by electrochemical oxidation in methanol.
Bacteriorhodopsin. The influence of the cyclohexene-ring methyls
Courtin, J. M. L.,Verhagen, L.,Biesheuvel, P. L.,Lugtenburg, J.,Bend, R. L. van der,Dam, K. van
, p. 112 - 119 (2007/10/02)
Four ring-demethylated retinals, viz. 1,1',5-tridemethylretinal, 1,1'-didemethylretinal, 1,5-didemethylretinal and 1-demethylretinal, have been synthesized via new and simple schemes.The properties of these modified retinals, their protonated Schiff bases and the corresponding bacteriorhodopsins have been studied and compared with the native system.These bacteriorhodopsin analogues have also been tested for their proton-pump efficiencies.A large decrease in proton-pump activity was found for the analogues lacking the 5-methyl group.On the whole, the opsin shifts of the modified bacteriorhodopsins were much lower than those of the native system.UV-Vis and 1H NMR data support a planar 6-s-trans conformation for the demethylated retinals in solution rather than a twisted 6-s-cis conformation (torsion angle 40-60 deg) as found in retinal.This explains the lower opsin shift and the better fit of these demethylated retinals in bacteriorhodopsin's binding site, which, in its native form, contains a 6-s-trans chromophore.
Electrochemical Oxidation of 1-Phenylthio-1-trimethylsilylalkanes
Yoshida, Jun-ichi,Isoe, Sachihiko
, p. 631 - 634 (2007/10/02)
Electrochemical oxidation of 1-phenylthio-1-trimethylsilylalkanes in the presence of alcohol resulted in facile cleavage of the carbon-silicon bond and formation of the corresponding acetals.
