113772-16-0

Basic information

• Product Name: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE
• Synonyms: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE;2,5-Dihydro-3-thiophenecarboxaldehyde
• CAS NO: 113772-16-0
• Molecular Formula: C₅H₆OS
• Molecular Weight: 114.17
• Product Categories: Aldehydes;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 113772-16-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 226.5 °C at 760 mmHg
• Flash Point: 114.4 °C
• Appearance: /
• Density: 1.326 g/cm³
• Vapor Pressure: 0.0818mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(113772-16-0)
• EPA Substance Registry System: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(113772-16-0)

Safety Data

• Hazardous Substances Data: 113772-16-0(Hazardous Substances Data)

Usage

General Description

2,5-Dihydrothiophene-3-carbaldehyde is a chemical compound with the molecular formula C6H8OS. It is a yellow to brown liquid with a pungent odor and is commonly used as a fragrance ingredient in perfumes and personal care products. It is also known for its use in the production of pharmaceuticals and agrochemicals. 2,5-Dihydrothiophene-3-carbaldehyde is a versatile building block in organic synthesis, capable of undergoing various chemical reactions such as Michael addition and nucleophilic substitution. It is important to handle this chemical with caution, as it may be harmful if inhaled, ingested, or comes into contact with the skin.

InChI:InChI=1/C5H6OS/c6-3-5-1-2-7-4-5/h1,3H,2,4H2

Upstream product

• 4594-63-2 3-hydroxy-tetrahydro-thiophene-3-carbonitrile 
• 40018-26-6 1,4-dithiane-2,5-diol 
• 107-02-8 acrolein 

Downstream Products

• 498-62-4 3-thiophene carboxaldehyde 

Relevant articles and documents

A short, practical synthesis of 3-thiophenecarboxaldehyde

The compound 3-thiophenecarboxaldehyde (2) was prepared in multi-kilogram quantities by a novel two-step process involving the condensation of acrolein with 1,4-dithiane-2,5-diol, followed by sulfuryl chloride-mediated oxidation.

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.