113777-22-3Relevant academic research and scientific papers
Copper-catalyzed formal C-N bond cleavage of aromatic methylamines: Assembly of pyridine derivatives
Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Huang, Liangbin,Jiang, Huanfeng
, p. 3774 - 3782 (2013/06/05)
An efficient copper-catalyzed C-N bond cleavage of aromatic methylamines was developed to construct pyridine derivatives. With neat conditions and facile operation, the fragment-assembling strategy affords a broad range of 2,4,6-trisubstituted pyridines in up to 95% yield from simple and readily available starting materials. Interestingly, when pyridin-2-yl methylamine was employed as the substrate, α-alkylation reaction of ketones readily occurred to give β-(pyridin-2-yl) ketones instead of the 2,4,6-trisubstituted pyridines.
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, Janos,Wagner, Gabor,Nogradi, Katalin,Bielik, Attila,Molnar, Laszlo,Bobok, Amrita,Horvath, Attila,Kiss, Bela,Kolok, Sandor,Nagy, Jozsef,Kurko, Dalma,Bakk, Monika L.,Vastag, Monika,Saghy, Katalin,Gyertyan, Istvan,Gal, Krisztina,Greiner, Istvan,Szombathelyi, Zsolt,Keser, Gyoergy M.,Domany, Gyoergy
scheme or table, p. 4371 - 4375 (2010/10/02)
Hit-to-lead optimization of a HTS hit led to new carbamoyloxime derivatives. After identification of an advanced hit (8d) the CYP enzyme inhibitory activity of this class of compounds was successfully eliminated. Systematic exploration of different parts of the advanced hit led us to some promising lead compounds with mGluR5 affinities comparable to that of MPEP.
MGLUR5 ANTAGONISTIC CARBAMOYL-OXIME DERIVATIVES
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Page/Page column 20-21, (2008/06/13)
The present invention relates to new mGluR5 receptor subtype preferring ligands of formula (I): (I) wherein R1 and R2 represent independently a substituent selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl and cyano; X is a C
