96254-05-6

Basic information

• Product Name: 2-(TRIFLUOROACETOXY)PYRIDINE
• Synonyms: 2-PYRIDYL TRIFLUOROACETATE;2-(TRIFLUOROACETOXY)PYRIDINE;2-(TRIFLUOROACETOXY)PYRIDINE 98%
• CAS NO: 96254-05-6
• Molecular Formula: C₇H₄F₃NO₂
• Molecular Weight: 191.11
• Product Categories: Heterocyclic Compounds;Building Blocks;C7 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines
• Mol File: 96254-05-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 60 °C0.3 mm Hg(lit.)
• Flash Point: 120 °F
• Appearance: /
• Density: 1.356 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.45mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Storage Temp.: 2-8°C
• BRN: 3607316
• CAS DataBase Reference: 2-(TRIFLUOROACETOXY)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETOXY)PYRIDINE(96254-05-6)
• EPA Substance Registry System: 2-(TRIFLUOROACETOXY)PYRIDINE(96254-05-6)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 8-10-21
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 96254-05-6(Hazardous Substances Data)

Usage

General Description

2-(Trifluoroacetoxy)pyridine is a chemical compound with the molecular formula C7H4F3NO2. It is a pyridine derivative with a trifluoroacetoxy group attached to the 2-position of the pyridine ring. 2-(TRIFLUOROACETOXY)PYRIDINE is commonly used as a building block in organic synthesis and is known for its ability to undergo various chemical reactions, including nucleophilic substitution, oxidation, and reduction. It has applications in the pharmaceutical and agrochemical industries, where it is utilized in the production of various active ingredients and intermediates. Additionally, 2-(trifluoroacetoxy)pyridine has been studied for its potential biological activities and is a subject of interest in medicinal chemistry research.

InChI:InChI=1/C7H4F3NO2/c8-7(9,10)6(12)13-5-3-1-2-4-11-5/h1-4H

Upstream product

• 142-08-5 2-Pyridone 
• 407-25-0 trifluoroacetic anhydride 
• 142-08-5 2-hydroxypyridin 

Downstream Products

• 1524-14-7 4-methylbenzyl trifluoroacetate 
• 338959-40-3 1-benzyl-2,3-dihydro-8-(4-trifluoroacetylpiperazin-1-yl)pyrrolo[3,2-g]isoquinoline 
• 287970-98-3 N-(2,6-diisopropyl-phenyl)-2,2,2-trifluoro-acetamide 
• 500-73-2 phenyl trifluoroacetate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 1549-45-7 cyclohexyl trifluoroacetate 
• 351-70-2 benzyl trifluoroacetate 
• 144181-67-9 N-(4-chloro-2-hydroxyphenyl)-2,2,2-trifluoroacetamide 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 10595-66-1 2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 16184-87-5 2,2,2-trifluoro-1-(2,4-dimethylphenyl)ethanone 
• 340-11-4 2,2,2-trifluoro-N,N-diphenylacetamide 
• 404-27-3 2,2,2-trifluoro-N-(4-nitrophenyl)acetamide 

Relevant articles and documents

2-(Trifluoroacetyloxy)pyridine as a Mild Trifluoroacetylating Reagent of Amines and Alcohols

A new trifluoroacetylating reagent, 2-(trifluoroacetyloxy)pyridine (TFAP), was prepared by the reaction of 2-pyridinol and trifluoroacetic anhydride.TFAP has been found to be effective in the trifluoroacetylation of aliphatic and aromatic amines and alcohols including phenol under mild conditions.The reaction of p-nitrophenol with TFAP in ether gave the hydrogen-bonded complex between the phenol and 2-pyridone.This reagent has also been shown to be useful for the intramolecular dehydration of aldehyde oximes and amides to give nitriles in high yields.