1137882-35-9Relevant academic research and scientific papers
Development of a robust and practical process for the Darzens condensation and α,β-epoxide rearrangement: Scope and limitations of the methodology
Zimbron, Jeremy Malcolm,Seeger-Weibel, Manuela,Hirt, Hans,Gallou, Fabrice
, p. 1221 - 1226 (2008/12/22)
A practical and robust process for the Darzens condensation of substituted benzaldehydes and subsequent α,β-epoxy rearrangement is reported. The process developed is both amenable to large scale and parallel synthesis. While electron-poor benzaldehydes gave mixtures of aryl ketones and 2-substituted aryl ketones in mediocre to low yields, electron-rich benzaldehydes were found to react in high yields with complete regioselectivity to form 2-substituted aryl ketones. Georg Thieme Verlag Stuttgart.
Development of a practical route for the manufacture of N-[5-(3-lmidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]acetamide
Hirt, Hans,Haenggi, Ruedi,Reyes, Jesus,Seeger-Weibel, Manuela,Gallou, Fabrice
, p. 111 - 115 (2012/12/31)
An efficient synthesis of a potent candidate in our respiratory program is described. The synthesis based on a key Darzens condensation-α,β- epoxide rearrangement circumvented the toxicity and safety issues encountered in the original synthesis route. Sub
